Top 12 tech stories of the year



















Microsoft's big Windows 8 push


SOPA backlash


Live-tweeting war


Apple maps stumble


Apple vs. Samsung


Facebook's botched IPO


The Instagram boom


Megaupload and Kim Dotcom


Mid-sized tablets make their mark


Nintendo launches Wii U


Yahoo hires Marissa Mayer


Tech's role in the 2012 election





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STORY HIGHLIGHTS


  • In 2012, older tech companies such as Microsoft tried to revamp their brands

  • The year kicked off with a huge online protest against SOPA

  • Facebook bought photo-sharing app Instagram, but its IPO was a disappointment

  • Apple released its iPhone 5 and iPad Mini but bungled its new mobile maps app




(CNN) -- In the tech world, 2012 was the year of the reboot. Older, established tech companies such as Microsoft, Yahoo and Nintendo all tried to restart their brands with bold new products and fresh blood in the executive suites.


Facebook struggled with its new life as a publicly traded company, and Instagram, the photo-sharing network it acquired in April, was dragged along for the ride.


There were inspiring stories, such as the Internet coming together to protest anti-piracy legislation. And there was darker news, like the Israeli military live-tweeting its strikes against Gaza.


And as always, the world's dominant and most closely watched tech company was all over the news. Apple did a little bit of everything in 2012, from hit new products (the iPad Mini) to high-profile failures (Apple Maps) to some old-fashioned courtroom drama in its patent war with Samsung.


Here are our picks for the top 12 tech stories of 2012. What did we leave out? Let us know in the comment section below.


Microsoft's big push


This was the year Microsoft took a big, bold and surprisingly fun step with a new version of Windows, an updated mobile operating system and its very own iPad rival.


The company, best known for its efficient but stodgy desktop software, needed to do something fresh to get customers' attention in 2012 and started with its flagship product. Windows 8 is a complete overhaul of the Windows operating system. Microsoft nixed the Start button and mixed a playful touchscreen interface with a more traditional desktop experience that runs on tablets, traditional computers, and hybrid machines.


The company also made a leap into the hardware market, releasing its first tablet, the Microsoft Surface, which ran a truncated version of the new Windows 8 operating system. And finally, there was Windows Phone 8, a major revamp of its smartphone operating system, which Microsoft hopes can compete with Apple's iOS and Google's Android.


It's still too soon to judge any of the new releases as successes or failures, but give Microsoft credit for taking chances.


SOPA backlash


In January, a pair of anti-piracy bills united the Internet in outrage. The proposed legislation, the Stop Online Piracy Act, or SOPA, and the Protect IP Act, or PIPA, would have restricted access to sites associated with pirated content, including the search engines and ad networks that do business with them.


The Internet cried censorship, and on January 18 some of the most popular sites blacked out their pages in protest. Reddit, Craigslist, Boing Boing, The Oatmeal, the English-language version of Wikipedia and thousands of other sites went dark. Even Google put a black censorship box over its logo. There were also petitions and organized boycotts of companies that supported the bills.


The protests worked, as both SOPA and PIPA were shelved. It was an impressive demonstration of the power of an organized Internet community.


Live-tweeting war


Violence and war have long been documented on Twitter and other social networks -- typically by journalists and by regular people on the ground (notably the Pakistani witness to the 2011 raid that killed Osama bin Laden).


But in November, the Israeli military took this concept to a new level. During its conflict with Palestinian forces in Gaza, the Israel Defense Force tweeted updates, including the news it had "eliminated" Hamas leader Ahmed Jabari. The military arm of Hamas responded on Twitter with its own provocations.


The back-and-forth between the warring sides signaled a jarring evolution in how war is broadcast in real time.


iPhone 5 and Apple Maps stumble


Every Apple hardware release is a big news story, starting with rumors months in advance and peaking with a well-oiled Apple press event, followed by usually glowing reviews and huge sales numbers. But in 2012, Apple made a major misstep when it released the iPhone 5 and its new operating system, iOS 6.


The company dropped the Google-powered maps that had come pre-installed on every iPhone since 2007. In its place, Apple introduced its own mapping app. Apple Maps looked stunning, with 3-D graphics and neat features like Flyover and turn-by-turn directions. All it was missing was transit directions and accuracy -- the maps were riddled with mistaken locations and outdated information.


The resulting criticism inspired an apology from CEO Tim Cook and led to an executive shakeup at Apple. Customers turned to third-party map apps until Google finally released an iOS version of its popular maps in December.


Apple vs. Samsung


It was the biggest tech trial of the year. Two of the top phone and tablet manufacturers went to war when Apple accused Samsung of infringing on its iPad and iPhone patents for a variety of tablets and smartphones. The drama culminated in a federal jury trial over the summer that offered a rare peek into how notoriously secretive Apple operates.


The story became huge because of the large amount of money at stake and the implications that its verdict would have on Samsung's business and the Android platform.


The jury decided in Apple's favor, awarding the company just over $1 billion in damages. But the case is far from over. Lawyers for both sides will continue bickering over potential appeals for months and possibly years to come.


Facebook's botched IPO


It was the most anticipated IPO of the year, and one of the largest ever for a tech company. Social-media darling Facebook looked primed for a big public opening: The company was valued at $104 billion, snapped up popular photo-sharing app Instagram and was still growing.


But then an array of problems and misjudgments led to a botched IPO in May, and the company's stock plummeted. The initial offer price of $38 was too high, too many shares were issued, its opening day was marred by Nasdaq's technical glitches, and underwriter Morgan Stanley was fined for improperly influencing share sales.


The stock price dropped significantly, hitting a low of $17.55 on September 4. Facebook is still struggling to recover some of its early-2012 luster.


The Instagram boom


Instagram started out scrappy two years ago as a fun little app for sharing sepia-shaded photos with friends. But when its user base skyrocketed, Facebook bought it for $1 billion in cash and shares of Facebook stock. That amount later dropped to $735 million as the value of Facebook shares plummeted.


By September, Instagram had more than 100 million users. The app capped off its big year with a rite of passage for social networks: a bungled update to its terms of service that sparked user outrage and led to a hasty backtrack by founder Kevin Systrom.


Instagram's challenge for 2013 is to figure out how to grow its free service into a business that makes money so that Facebook can begin to get its money's worth.


Megaupload and Kim Dotcom


The Megaupload case would have been mildly interesting on its own. A popular file-sharing company and its various sites were shut down by the F.B.I for piracy. But when Megaupload founder Kim Dotcom was arrested in January at his lavish New Zealand estate, he went from unknown entrepreneur to a flamboyantly rich cult hero.


Dotcom (he legally changed his last name from Schmitz in 2005) did what any self-respecting boy video-game nerd would do with millions of dollars. He bought a yacht, helicopter, luxury cars and motorcycles. He lived with his model wife in a $24 million rented mansion in New Zealand where he spent hours playing "Call of Duty: Modern Warfare 3," earning a spot as the top-ranked player in the world.


But after Dotcom was jailed and his assets were seized, he slowly emerged as a leader for Internet freedom activists who thought he was unfairly targeted. He's still fighting the charges and using his newfound fame to launch new projects. His current plans include a new file-sharing site that encrypts all its files, and a streaming music service called Megabox.


Mid-sized tablets take off


It was the rare case of Apple following a trend instead of setting it. Apple introduced its 7.9-inch iPad Mini in October to take on its new rivals in the tablet market: cheaper 7-inch devices from Google and Amazon. While the Kindle Fire and Nexus 7 were only selling modestly compared to the iPad, Apple quickly recognized the growing demand for a smaller, more portable device.


The iPad Mini proved especially notable because Apple's late CEO, Steve Jobs, famously stated a 7-inch tablet would never make it in the market because it was "too big to compete with a smartphone; too small to compete with an iPad." This may have been one of those rare cases in which Jobs was wrong.


Nintendo launches Wii U


In November, Nintendo released a new version of its popular Wii game console, which while groundbreaking when launched in 2006 was badly in need of a refresh.


The Wii U's most novel feature is a touchscreen tablet controller called a GamePad, which communicates with the main console. Inside the tablet are motion control sensors, speakers, a camera, buttons and other bells and whistles -- all of which the gamer uses to interact with what's happening on the larger screen.


It's a bold move for the company and brings a new perspective to console gaming, although the Wii U has received mixed reviews so far.


Yahoo hires Marissa Mayer


Aging Internet giant Yahoo was facing slumping revenues and internal strife in July when it hired Google exec Marissa Mayer as its new chief executive. The hire made headlines for many reasons: Mayer was a bold choice that showed Yahoo was serious about shaking things up. She was also young, a Silicon Valley power player, and a woman who was expecting her first child.


There was much media hand-wringing over her pregnancy, with some pundits wondering aloud whether Mayer could juggle a newborn baby and a demanding new job. Many saw her as a role model for working mothers.


But when the news settled, the real question returned: Could Mayer save the floundering Yahoo? So far she has shaken up Yahoo's executive team, given employee morale a much-needed boost and begun to improve the company's mobile offerings, including a stunning new Flickr app.


It will take a while to properly gauge her impact, but investors seem optimistic. Yahoo's stock price has risen $4 a share since her hiring was announced.


Tech's role in the presidential election


Technology issues such as net neutrality weren't discussed much during the 2012 presidential election, but tech played a huge role in rallying supporters and getting out the vote. President Obama, arguably the most tech-savvy of U.S. presidents, went on Google Plus and Reddit to take questions from voters.


And both his campaign and that of his GOP challenger, Mitt Romney, sent social media messages almost daily in attempts to sway media reports and public opinion.


But the most impressive use of tech took place behind the scenes, where both sides used new and powerful computer databases to target voters. The Romney campaign's get-out-the-vote program, called Orca, suffered technical glitches on Election Day and was perceived to have been outflanked by Obama campaign software which compiled massive amounts of data on voters and dispatched volunteers to pinpoint locations across the country.







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Classes delayed for Sandy Hook Elementary kids

NEWTOWN, Conn. The children at the Sandy Hook Elementary school won't be returning to classes for another week, but officials from the town, school district and local agencies are doing their best in the meantime to keep them occupied following a massacre at their school two weeks ago.

The students have not attended school since a gunman killed 20 of their schoolmates and six adults on Dec. 14. They are slated to return to a different school next Thursday.

In the meantime, they've been treated to field trips, toy giveaways and some organized play time.

"A couple of the teachers have done pizza parties," said Janet Robinson, Newtown's school superintendent. "Another met her kids at the library so they could have a little reading time together. The most important thing has been connecting the students back to their teacher and their classmates."




Play Video


Newtown schools superintendent: We have to move forward






39 Photos


Victims of Conn. school shooting






Play Video


Newtown police get a break on Christmas



The Newtown Youth Academy, a nonprofit sports center, opened its doors to all kids in town at no cost shortly after the shooting. But from 9 a.m. to 2 p.m. last week, the building's turf field, basketball and tennis courts, and giant inflatable obstacle course were reserved just for Sandy Hook Elementary students.

There have been arts and crafts for the smaller kids, as well as face-paintings. Some celebrities, including two members of the Harlem Globetrotters and former University of Connecticut basketball star Tina Charles, also have stopped by to play with the children.

UConn's men's basketball team and its coaches made a trip to the academy Thursday and played games with the kids, posed for photos and signed autographs. "It was great for us to be able to see some smiles on their faces and to spend some time with them," Coach Kevin Ollie said.

On Thursday afternoon, school buses were loading up at the Youth Academy for a trip to Stamford and a larger complex, Chelsea Piers, which also has ice rinks and an indoor swimming pool, said academy owner Peter D'Amico. Sports celebrities, such as Brooklyn Nets forward Kris Humphries, planned to meet them there.

"The idea was to get them away from the house, the television and all the coverage of this tragedy and get them to a place where kids can just be kids," said D'Amico, a longtime youth coach in town.

University of Connecticut psychologist Julian Ford, who spent time counseling in Newtown in the first days after the shooting, said it's important for the grieving process to include an outlet that lets children know that while things will never be the same, it's OK to enjoy life.

"They are all going to be thinking about what happened," he said. "That, unfortunately, is inescapable. But this gives them a chance to say, `Life is carrying on.' Nothing will be the same, but it's also continuing in ways that it should be."

Some students and their parents on Thursday toured the Chalk Hill school in Monroe, a former middle school being reopened next week for the Sandy Hook students. An open house is planned for Wednesday.

"Getting back into the school is like getting back on the horse," Robinson said. "Some of the scariness is gone once they cross that threshold. They are just so happy to see their teachers."

State police said they plan to keep their contact with the children to a minimum as they continue investigating the shooting.

"We certainly don't want to traumatize them any more than they've already been traumatized," said Lt. J. Paul Vance, the department's spokesman. "If (an interview is) not necessary it won't be done. Our investigators will make all those determinations."

In the meantime, Ford has encouraged parents to keep the kids involved in a normal holiday routine and deal with the tragedy as it comes up, rather than making it a focal point of their lives.

David Connors, who has 8-year-old triplets who attend Sandy Hook, said he and his wife have made play dates with their friends, brought the kids to see family for the holidays and participated in the class get-togethers and recreation events.

"That's been, I think, helpful at least in the short term just to kind of keep them doing things, keep them seeing their friends and being nearby and talking to family," Connors said.

Todd Wood of Newtown has five children, the youngest age 4 and the oldest in college. His children's piano teacher lost a child in the shooting, and the family knows other victims as well.

He said he's found that each child has reacted differently to the tragedy. He said he is not making the shooting the center of his family's life but is not pretending it didn't happen, either.

"We did Christmas, we had our lights here, we've tried to make things as normal as possible," he said. "But we also went down to see the memorials. I don't want to shield them from it. I want to let them grieve in their own way."

Ford said that is healthy. He said children will remember their friends as they go about doing normal kid things.

Chris Wolcott, the sport's academy's operations manager, said the best part of having the kids at the center is that the tragedy is pushed aside, at least for a little while.

"A couple times someone would drop a weight (in the facility's health center) and you would hear a bang and there would be a kid who would freeze for a second," he said. "But that would last a split-second. Most of the time, everyone just had a great time."

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Gen. 'Stormin' Norman Schwarzkopf Dead at 78













H. Norman Schwarzkopf, the retired general credited with leading U.S.-allied forces to a victory in the first Gulf War, has died at age 78, a U.S. official confirmed to ABC News.


He died today in Tampa, Fla., where he lived in retirement, a U.S. official told the Associated Press.


Schwarzkopf, called "Stormin' Norman" because of his reportedly explosive temper, actually led Republican administrations to two military victories: a small one in Grenada in the 1980s and a big one as de facto commander of allied forces in the Gulf War in 1991.


"'Stormin' Norman' led the coalition forces to victory, ejecting the Iraqi Army from Kuwait and restoring the rightful government," read a statement by former Secretary of State Colin Powell, who was chairman of the Joint Chiefs of Staff during the Gulf War. "His leadership not only inspired his troops, but also inspired the nation."


Schwarzkopf's success during that fight, also known as Operation Desert Storm, came under President George H.W. Bush, who through his office today mourned "the loss of a true American patriot and one of the great military leaders of his generation."


"Gen. Norm Schwarzkopf, to me, epitomized the 'duty, service, country' creed that has defended our freedom and seen this great nation through our most trying international crises," Bush said. "More than that, he was a good and decent man -- and a dear friend."








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Gen. Schwarzkopf's '5 Minutes of Unimportant Questions' Watch Video









George H.W. Bush Hospitalized in ICU After 'Setbacks' Watch Video





Bush's office released the statement though the former president, himself, was ill, hospitalized in Texas with a stubborn fever and on a liquids-only diet.


Defense Secretary Leon Panetta today called Schwarzkopf "one of the great military giants of the 20th century."


Schwarzkopf, the future four-star general, was born Aug. 24, 1934, in Trenton, N.J. He was raised as an army brat in Iran, Switzerland, Germany and Italy, following in his father's footsteps to West Point, earning an engineering degree and being commissioned as a second lieutenant in 1956.


Schwarzkopf's father, who shared his name, directed the investigation of the Lindbergh baby kidnapping as head of the New Jersey State Police, later becoming a brigadier general in the U.S. Army.


The younger Schwarzkopf earned three Silver Stars for bravery during two tours in Vietnam, gaining a reputation as an opinionated, plain-spoken commander with a sharp temper who would risk his own life for his soldiers.


"He had volunteered to go to Vietnam early just so he could get there before the war ended," said former Army Col. William McKinney, who knew Schwarzkopf from their days at West Point, according to ABC News Radio.


In 1983, as a newly-minted general, Schwarzkopf once again led troops into battle in President Reagan's invasion of Granada, a tiny Caribbean island where the White House saw American influence threatened by a Cuban-backed coup.


But he gained most of his fame in Iraq, where he used his 6-foot-3, 240-pound frame and fearsome temper to drive his forces to victory.


"He was known as a soldier's general," said retired Maj. Gen. Donald Shepperd, as he explained the "Stormin' Norman" nickname to ABC News Radio. "In other words, he really liked the troops and was soft on the troops. But boy, on his general officers, his officers, his NCO's, he was very, very tough and he had a real quick temper."


Gruff and direct, Schwarzkopf said during the Gulf War that his goal was to win the war as quickly as possible and with a focused objective: getting Iraq out of Kuwait.






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Three gods: The hardest logic puzzle ever


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Nicaraguan farmers stay put despite volcano warning






CHINANDEGA, Nicaragua: Some 1,500 farmers living on the slopes of the San Cristobal volcano refused to leave, despite being ordered to evacuate as the volcano spewed gas, sand and ash.

"People have not evacuated because we do not want to go and leave the area abandoned," Maria Pereira told AFP.

Pereira lives in "Grecia 4", a community of about 600 people at the base of the volcano, in the Chinandega department.

She said columns of ash "bathed the trees, houses, and roads in white" and "pretty sand fell" in the morning. She said by early afternoon volcanic activity had decreased, though in the evening new columns of ash shot up.

In another community near the volcano, Bethlehem, some farmers resisted efforts of Civil Defence officials to convince them to obey the evacuation order.

Around 140 Civil Defence troops have been deployed to "persuade" farmers to move away from the danger zone, state deputy Colonel Nestor Solis told reporters.

The government issued a yellow alert on Wednesday, ordering the evacuation of 300 families living near the volcano.

Reiterating the evacuation order on Wednesday, first lady Rosario Murillo, a government spokeswoman, said "the situation of the volcano is unstable".

But she did not specify how many had obeyed the evacuation order or where they are being housed.

San Cristobal, the tallest of Nicaragua's seven active volcanoes, is believed to have erupted for the first time in 1685.

- AFP/al



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Decluttering before the New Year




Time off work during the holidays is a perfect time to tidy up your home and work spaces to start the New Year right.




STORY HIGHLIGHTS


  • Do your New Year's resolutions include a push to clean up? Here are some tips to start

  • Being organized is about being in control, says professional organizer Susan Fleischman

  • Cleaning clutter can eliminate the need to buy what you simply can't find




(CNN) -- Whatever other resolutions we make leading up to the New Year -- to call Mom more often, lay off the late-night snacks -- getting ourselves organized is likely near the top of the list. And that often means clearing out the clutter that keeps us from functioning efficiently, whether we're at work or at home.


Many employees -- whether they go to actual offices or do their jobs from home -- find the last week of the calendar year is ideal for sorting through e-mails, clearing their desks, and reorganizing their work spaces. Sorting through stuff is rarely fun, but those who tackle it now will find themselves a step ahead when their now-vacationing colleagues and clients come staggering back after the holidays.


According to the National Association of Professional Organizers, which sponsors the annual "Get Organized Month" each January to help folks take control of their time, tasks and possessions, 83% of members polled say that "paper organization" ranks highest on their individual and corporate clients' to-do lists. For people taking time off between Christmas and New Year's, this week offers a chance to get things in order before 2013 arrives.


Devoting time to both physically and mentally clearing out the "old" and embracing the "new" is about more than just getting rid of stuff. Being organized is really about being in control, says Susan Fleischman, a Chicago-based professional organizer, home stager and founder of clutterfree.



"As joyous as the holidays can be, the period between Thanksgiving and New Year's is probably one of the most stressful of the year for people," she says. That's why spending the week after Christmas decluttering "really helps you recover and detox from the hustle and bustle of the holidays.


"It's very symbolic -- we're ramping up to the ultimate do-over. We all get to turn the calendar page and make a fresh start."


For those at work, says Fleischman, "the phone stops ringing, there are fewer meetings. Real work probably comes to a screeching halt. There are far fewer reasons to keep letting getting organized fall to the bottom of the to-do list." And these days, when employees often feel compelled to work harder and longer, being organized can be a real competitive advantage.


NAPO Industry Member Director Mary Dykstra says that on average, Americans waste time amounting to between six and 12 weeks a year searching for things in their offices and homes. "Just imagine if you could get out from under that clutter and spend that time helping your company build their business and ultimately, your career," says Fleischman, who was a public relations and marketing executive before launching her professional organizing business.




"Every minute counts when it comes to impressing the boss, your colleagues and clients. At work, we strive to project that we're knowledgeable, in control and experts. We're constantly accessing, sharing, reacting to information. Being able to put your hands on the information or generate some information means the better you'll be able to rise to the top and have clarity of thought and creativity, and maximize productivity."


But what about moving from work to the home front? Cynthia Ewer, the Washington state-based editor of OrganizedHome.com and the author of "The Complete Idiot's Guide to Getting Organized Fast-Track," suggests we use this in-between-holidays week to step back and reflect on our habits and how well they're working for us at home.


It's important to remember, says Ewer, that "there are different personality types. "Organized" is what works for you. There are filers -- people who love folders. They want the serenity of knowing where things are. Pilers like to keep their eyes on their stuff. Deniers have bags of paperwork shoved into closets. Instead of using a "What-does-it-look-like?" yardstick, it's a "How-will-it-work?" question. Know yourself, and come up with solutions that reflect who you are, she says.


After all, she says, " 'It's here somewhere' is the most frustrating phrase in the English language."


Cutting clutter also can boost the bottom line. "How many times do you go to the store and buy the things you couldn't find?" asks Fleischman. But cleaning up and cleaning out also can generate money, says Ewer.


"It can be a real fun process to turn your clutter into cash."


Nab tax deductions by donating cleared-out items to nonprofit organizations. Declutterers can send usable books, DVDs, video games, and music to third-party merchants in exchange for gift cards through the Amazon Trade-In Program. Even computer manufacturers like Apple offer gift cards to customers who send in an old iPhone, iPad, or computer for reuse or recycling if those devices still have monetary value.


"Leading an orderly life is about saving time, saving money, reducing stress," says Fleischman, who also blogs about organizing tips and clutter makeovers. "And that's energy you can spend on leisure pursuits, which is very important to emotional well-being."


Some tips for cutting through the workplace and home clutter this holiday week:


• Stockpile your supplies. Fleischman advises making sure you've got the right trash bins, shredders, file folders and markers at your fingertips before you start sorting and tossing.
• Take it a zone at a time. Your office, home and car didn't become a mess overnight, so declutter in increments. Fleischman suggests starting with desktops, then floors, then moving on to file cabinets and bookcases.
• Go from horizontal to vertical piles. If you're purging papers, clear those piles from your desk and the floor by placing newly sorted files in a cabinet or an upright vertical file. This way, your eyes can quickly scan and identify what you need at a glance.
• Free up the fridge. "Get the ghosts of Christmas past out of there -- all those little cans of this and that, the beef sticks from the gift basket no one can bear to throw out," says Ewer. Besides, this clean-up also will save you some calories.
• Be realistic. If you really write out bills at the kitchen table and not in the home office, says Ewer, get yourself a wheeled cart you can roll where the work gets done. If your kids' toys actually live in the family room -- not in the bedroom toy box -- create a storage solution there.


"Look at your patterns of living and organize yourself accordingly."







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Study: Cancer drug substitute linked to higher rate of relapse

(CBS News) Abby Alonzo was 10 when she was diagnosed in 2009 with Hodgkin's lymphoma, a cancer of the immune system. With proper treatment, 90 percent of patients survive.

"It wasn't as hard for me as I think it as it was on my mom and my brother and my dad," Abby says.

Abby began a seven-drug regimen. But in 2010, doctors told Abby's mother, Katie, there was a nationwide shortage of one of the medicines -- mechlorethamine.

"I started to get a little hysterical, 'Why is it not available?'" says Katie.

In 2010, 23 cancer drugs had shortages. Reasons include manufacturing problems and low profit margins for the drugs, which became mostly generic, and therefore less expensive, than brand-name.

"There is really nothing you can do," Katie says. "You do what your doctor tells you to do, you take what medications your doctor tells you to take, and you pray that it works. And if one of those medications isn't available, you just take, you know, the next-best thing."

Doctors thought the next-best thing for patients like Abby was a drug called cyclophosphamide.

Life-saving cancer drugs for children stuck in federal legislative limbo

But a new study in the New England Journal of Medicine showed 88 percent treated with the original drug were cancer-free after two years -- compared to only 75 percent of those receiving the replacement drug.

"This is the first study to clearly show that when we substitute one drug for what we think is just an equally good drug, that's not always going to be the case. So it's demonstrating a negative impact on patients," says Dr. Richard Gilbertson, the director of cancer care at St. Jude Children's Research Hospital.

Abby was one of the patients who relapsed. She then needed a bone marrow transplant, radiation and more chemotherapy. Right now, she shows no signs of cancer.

"What if I relapsed again? Or what if something else happens? You know, it is just really scary, that part," Abby says.

The original drug in the study is finally available again after almost three years. But there are still 13 drugs used in cancer therapy, and a total of 100 on the FDA shortage list.

Congress passed legislation last July giving the FDA more authority to deal with cancer drug shortages. That new law has made a big difference, and the key provision is the requirement that drug manufacturers let the FDA know when there's an impending shortage.

Since that law was passed, there has been a doubling of those notifications, so the FDA can increase imports from abroad and tell other manufacturers in the United States to step up production.

Another provision in that law is that the FDA set up a task force looking at other possible solutions to the drug shortage crisis, and they're required to submit that report to Congress by this coming July.

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Toyota Agrees to $1B Settlement in Acceleration Case












Toyota has agreed to pay more than $1 billion to customers to settle a class action lawsuit that alleged its vehicles accelerated dangerously and without warning, according to statements by the carmaker and the plaintiffs' attorney.


The deal, which still needs approval by a federal judge in California, includes a $250 million fund to be paid to Toyota owners who sold their cars at a loss following reports of vehicle malfunctions, as well as the installation of a brake override system in about 3.25 million vehicles


An additional $250 million fund will be created to pay those owners whose vehicles are not eligible for the retrofitted brakes.






David Zalubowski/AP PHoto







Toyota recalled more than 14 million vehicles after reports of sudden, unexplained acceleration in several models began to surface between 2009 and 2010. There were also reports of brake problems with the Prius hybrid.


Toyota insists that it was not an electrical flaw that caused the acceleration problems, but driver error, floor mats and sticky gas pedals.


Both the National Highway Traffic Safety Administration and NASA have said there is nothing in wrong with programs that run the vehicles' onboard computers


"From the very start, this was a challenging case," said Steve Berman, the plaintiffs' lawyer. "We brought in automotive experts, physicists and some of the world's leading theoreticians in electrical engineering to help us understand what happened to drivers experiencing sudden acceleration."


The settlement also includes $30 million to be given to outside groups to study automotive safety.


In a statement, Toyota agreed to the deal.


"In keeping with our core principles, we have structured this agreement in ways that work to put our customers first and demonstrate that they can count on Toyota to stand behind our vehicles." said Toyota spokesman Christopher P. Reynolds.



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New Scientist 2012 holiday quiz

















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THIS was the year we held our breath in almost unbearable anticipation while we waited to see whether physicists at the Large Hadron Collider would finally get a clear view of the Higgs boson, so tantalisingly hinted at last December. Going a bit blue, we held on through March when one of the LHC's detectors seemed to lose sight of the thing, before exhaling in a puff of almost-resolution in July, when researchers announced that the data added up to a fairly confident pretty-much-actual-discovery of the particle.












Early indications were that it might be a weird and wonderful variety of the Higgs, prompting a collective gasp of excitement. That was followed by a synchronised sigh of mild disappointment when later data implied that it was probably the most boring possible version after all, and not a strange entity pointing the way to new dimensions and the true nature of dark matter. Prepare yourself for another puff or two as the big story moves on next year.













This respirational rollercoaster might be running a bit too slowly to supply enough oxygen to the brain of a New Scientist reader, so we have taken care to provide more frequent oohs and aahs using less momentous revelations. See how many of the following unfundamental discoveries you can distinguish from the truth-free mimics that crowd parasitically around them.












1. Which of these anatomical incongruities of the animal kingdom did we describe on 14 July?












  • a) A fish, found in a canal in Vietnam, that wears its genitals under its mouth
  • b) A frog, found in a puddle in Peru, that has no spleen
  • c) A lizard, found in a cave in Indonesia, that has four left feet
  • d) A cat, found in a tree in northern England, that has eight extra teeth

2. "A sprout by any other name would taste as foul." So wrote William Shakespeare in his diary on 25 December 1598, setting off the centuries of slightly unjust ridicule experienced by this routinely over-cooked vegetable. But which forbiddingly named veg did we report on 7 July as having more health-giving power than the sprout, its active ingredient being trialled as a treatment for prostate cancer?












  • a) Poison celery
  • b) Murder beans
  • c) Inconvenience potatoes
  • d) Death carrots

3. Scientists often like to say they are opening a new window on things. Usually that is a metaphor, but on 10 November we reported on a more literal innovation in the fenestral realm. It was:












  • a) A perspex peephole set in the nest of the fearsome Japanese giant hornet, to reveal its domestic habits
  • b) A glass porthole implanted in the abdomen of a mouse, to reveal the process of tumour metastasis
  • c) A crystal portal in the inner vessel of an experimental thorium reactor, to reveal its nuclear fires to the naked eye
  • d) A small window high on the wall of a basement office in the Princeton physics department, to reveal a small patch of sky to postgraduate students who have not been outside for seven years

4. On 10 March we described a new material for violin strings, said to produce a brilliant and complex sound richer than that of catgut. What makes up these super strings?












  • a) Mousegut
  • b) Spider silk
  • c) Braided carbon nanotubes
  • d) An alloy of yttrium and ytterbium

5. While the peril of climate change looms inexorably larger, in this festive-for-some season we might take a minute to look on the bright side. On 17 March we reported on one benefit of global warming, which might make life better for some people for a while. It was:












  • a) Receding Arctic sea ice will make it easier to lay undersea cables to boost internet speeds
  • b) Increasing temperatures mean that Greenlanders can soon start making their own wine
  • c) Rising sea levels could allow a string of new beach resorts to open in the impoverished country of Chad
  • d) More acidic seawater will add a pleasant tang to the salt water taffy sweets made in Atlantic City

6. In Alaska's Glacier Bay national park, the brown bear in the photo (above, right) is doing something never before witnessed among bearkind, as we revealed on 10 March. Is it:












  • a) Making a phonecall?
  • b) Gnawing at a piece of whalebone to dislodge a rotten tooth?
  • c) Scratching itself with a barnacle-covered stone tool?
  • d) Cracking oysters on its jaw?

7. Men have much in common with fruit flies, as we revealed on 24 March. When the sexual advances of a male fruit fly are rejected, he may respond by:












  • a) Whining
  • b) Hitting the booze
  • c) Jumping off a tall building
  • d) Hovering around the choosy female long after all hope is lost

8. While great Higgsian things were happening at the LHC, scientists puzzled over a newly urgent question: what should we call the boson? Peter Higgs wasn't the only physicist to predict its existence, and some have suggested that the particle's name should also include those other theorists or perhaps reflect some other aspect of the particle. Which of the following is a real suggestion that we reported on 24 March?

























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Stevie Wonder, Gilberto Gil give Rio Christmas cheer






RIO DE JANEIRO: US singer Stevie Wonder joined Brazil's Gilberto Gil late Tuesday for a massive free Christmas concert on Rio's Copacabana beach attended by half a million people.

"Tudo bem? (Everything all right?)" Wonder shouted out to the crowd in Portuguese after being led on stage by his sons.

Dressed in a golden suit, the blind singer began his set with "What a Wonderful World", then performed hits like "I Just Called to Say I Love You", "You Are the Sunshine of My Life" and, to sing a cover of the late Michael Jackson's "The Way You Make Me Feel."

Earlier, Gil opened the show with "Realce" and "A Novidade" on a stage set with the exclusive Copacabana Palace Hotel as a backdrop.

"Good night Rio, Merry Christmas. Thank you for the gift of your presence," he said.

Up to a million spectators had been initially expected, but police estimates cited in local media put the number at 450,000 to half a million people who braved sweltering temperatures around 40 degrees Celsius on one of the hottest evenings of the year.

During a benefit concert a week ago, Wonder and Gil performed for thousands of people who paid a $400 entry fee each.

Rio is expecting to host 752,000 tourists for its lavish New Year's Eve celebrations.

Throughout the Southern hemisphere's summer season, which began on December 21 and ends in March, about 3.2 billion tourists are expected to flock to the city and spend $2.6 billion, according to Tourism Ministry figures.

For February's Carnival, the state government hopes 900,000 tourists will visit the city and spend about $665 million.

-AFP/fl



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