British PM to offer "in-or-out" referendum on EU






LONDON: Prime Minister David Cameron will on Wednesday propose holding a referendum after 2015 giving British people the choice of staying in or leaving the European Union.

Cameron will say in a long-awaited speech in London that he wants to renegotiate the terms of Britain's membership because "public disillusionment with the EU is at an all-time high", and then put the new terms to the people.

According to pre-released excerpts, Cameron will say his Conservative party will make the pledge in its campaign for the general election scheduled to take place in two years' time.

"The next Conservative manifesto in 2015 will ask for a mandate from the British people for a Conservative government to negotiate a new settlement with our European partners in the next parliament," the speech says.

"And when we have negotiated that new settlement, we will give the British people a referendum with a very simple in-or-out choice to stay in the EU on these new terms, or come out altogether. It will be an in-out referendum."

If a Conservative government wins outright victory, a referendum would be held in the first half of the next parliament, he adds.

Cameron will say he believes a referendum on British membership of the 27-nation bloc is necessary because in its current form the EU is intruding into British life.

"People feel the EU is heading in a direction they never signed up to. They resent the interference in our national life by what they see as unnecessary rules and regulation. And they wonder what the point of it all is," he will say.

Cameron had been due to give the speech in Amsterdam last Friday but postponed it because of the Algeria gas plant hostage crisis.

In the re-scheduled speech, Cameron says he understands the "impatience" of those who want to hold a referendum immediately, but insists the time is not right.

"I don't believe that to make a decision at this moment is the right way forward, either for Britain or for Europe as a whole," it says.

"A vote today between the status quo and leaving would be an entirely false choice."

Explaining why he wants to wait, Cameron will say the eurozone crisis will leave the EU transformed "perhaps beyond recognition" and that Britain wants to help shape the future of the bloc that emerges from it.

Cameron has faced pressure from the eurosceptic rightwing of the Conservative Party to take a stand on Europe, an issue that has long divided the party.

But his insistence on holding a referendum with a stark in-or-out choice will anger many of Britain's fellow EU member states, as well as his coalition government partners, the pro-Europe Liberal Democrats.

It will also dismay many business leaders and the opposition Labour party, who have warned Cameron that to offer the possibility of a referendum risks creating uncertainty and will lead Britain to the edge of an "economic cliff".

Cameron has also faced warnings from Britain's close ally the United States against isolating the country from the EU.

The speech has been delayed a number of times.

Plans to give it first emerged six months ago, and there was talk that Cameron might deliver it at the Conservative party's annual conference in October, followed by reports that he would give it at Christmas.

The speech was then widely expected on January 22, but Cameron moved it forward when it emerged that it clashed with commemorations for the 50th anniversary of Franco-German reconciliation following World War II.

Then the Algeria crisis intervened to force another change of plans.

- AFP/al



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Tapper talks Benghazi and his book





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Evidence shows bold L.A. priest abuse cover-up

(CBS News) LOS ANGELES - There is new evidence that leaders of the Catholic Church in Los Angeles maneuvered secretly to shield priests accused of sexually abusing children.

Documents just released indicate they never told parishioners -- or the police -- what they knew.

"What we're seeing in these files is but a glimpse into a very, very dark, and endless tunnel of secrecy, of abuse, of silence," said Raymond Boucher, a former altar boy and current lead attorney, representing some 500 victims of sex abuse by priests in the archdiocese of Los Angeles.

Files show L.A. archdiocese manipulation in abuse cases

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Raymond Boucher

Raymond Boucher


/

CBS News

The documents offer the strongest evidence yet of a cover-up that reached to the very top of Los Angeles clergy: Then-archbishop, now-retired Cardinal Roger Mahony.

"That has always been paramount for the church for decades: Protect itself from scandal," Boucher said.

Many of the documents are correspondence between Mahony and Monsignor Thomas Curry, his chief adviser on sex abuse. One concerns whether to allow Monsignor Peter Garcia to return to his duties in L.A. He had secretly been sent away for treatment in New Mexico for sexually abusing as many as 17 youngsters.

No one in the church hierarchy alerted authorities.

Mahony wrote on July 22, 1986: "I believe if Monsignor Garcia were to reappear here within the archdiocese we might very well have some type of legal action filed in both the criminal and civil sectors. Signed, sincerely yours in Christ, most reverend Roger Mahony."

Monsignor Curry concurred: "There are numerous - maybe 20 - adolescents or young adults that Peter Garcia was involved with in a first degree felony manner. The possibility of one of these seeing him is simply too great."

Cardinal Mahony issued this statement Tuesday to the victims: "I pray for them every single day."

It ends simply: "I'm sorry."

Victims held a press conference Tuesday. Manny Vega says was abused from age 10 to 15.

"Conscious, clear decisions were made to hide these priests and move them around and never, never did they consider the well-being of the children that they destroyed and left behind," Vega said.

Monsignor Garcia has passed away, and Monsignor Curry did not respond to requests for comment from CBS News.


As many as 30,000 more documents from the archdiocese sex abuse settlement are to be released in the coming weeks.

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Teen Planned to Attack Walmart After Killing Family













The New Mexico teenager who used an assault rifle to kill his mother, father and younger siblings told police he hoped to shoot up a Walmart after the family rampage and cause "mass destruction."


Police said they are also considering charging the shooter's 12-year-old girlfriend.


According to new information released by police today, Nehemiah Griego, the 15-year-old son of an Albuquerque pastor, had plans to kill his family, his girlfriend's family, and local Walmart shoppers for weeks before he acted on the impulse on Sunday.


"Nehemiah said after killing five of his family members he reloaded the weapons so that he could drive to a populated area to murder more people," a police report from the incident stated.


"Nehemiah stated he wanted to shoot people at random and eventually be killed while exchanging gunfire with law enforcement," the report said.


The shooting spree began shortly around 1 a.m. on Sunday, when Griego snuck into his parents' bedroom while his mother, Sara Griego, was asleep. There he raided the closet where the family kept their guns, and immediately used a .22 rifle to kill her, according to the Bernalillo County Sheriff's Department.


Griego's 9-year-old brother was sleeping with his mother at the time and woke up. When Griego told the boy his mother was dead, the youngster didn't believe him, according to a police report.


"So Nehemiah picked up his mother's head to show his brother her bloody face," the report states. "Nehemiah stated his brother became so upset so he shot his brother in the head."






Susan Montoya Bryan/AP Photo











15-Year-Old Son Suspected in Family Shooting Watch Video











Sikh Temple Shooting: Gunman Killed, 6 Others Dead Watch Video





He then went into his sisters' bedroom. "Nehemiah stated when he entered he noticed that his sisters were crying and he shot them in the head," the police report states. The girls were 5 and 2 years old.


The teenager waited for his father to come from his overnight shift working at a nearby rescue mission. When his father, Greg Griego, walked into the home around 5 a.m., unaware of what had taken place, Griego shot him multiple times with the AR-15 rifle, Sheriff Dan Houston said today.


Greg Griego was a former church pastor at Calvary Church in Albuquerque, and worked as a chaplain at a local jail where he counseled convicts. The family was very involved in the church, according to its website.


The complaint said Griego took a photo of his dead mother and "sent it to his girlfriend."


Griego then packed up the guns, including two shotguns, as well as ammunition for the rifles, and planned to drive to a Walmart to shoot additional people.


Houston said today that Griego called his 12-year-old girlfriend Sunday and ended up spending the entire day with her rather than going to the Walmart. Around 8 p.m. on Sunday, the pair drove to Calvary Church, and Griego said his family had died in a car crash. Someone on the church's staff then called 911, Houston said.


"At this time, Nehemiah had been contemplating this for some time. The information that Nehemiah had contemplated going to the local Walmart and participating in a shooting in there is accurate," Houston said. "There is no information at all that he went to church to cause anyone bodily harm there. The suspect also contemplated killing his girlfriend's parents."


The girlfriend's name was not released, but police are investigating whether to press any charges against her, Houston said. Houston said she had some knowledge about the deaths during the day Sunday.


Griego told cops he sent a picture of his dead mother to his girlfriend after the murder.


Sheriff's deputies were dispatched to the Griego home around 9:15 p.m. on Sunday and arrived 10 minutes later, where they found the five bodies.


Griego lied to investigators about the attack, telling them he came home around 5 a.m. that morning and found his family dead. He said he then took the guns to protect himself.


Griego quickly admitted to the crime when pressed by police, telling investigators he was "frustrated" with his mother. Deputies said he was "unemotional" and "very stern" during the confession.






Read More..

Today at New Scientist: 21 January 2013







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Wind power delivers too much to ignore

Although aesthetic concerns need to be heard, qualms about wind's reliability are wide of the mark, argues an energy policy researcher



Quadruple DNA helix discovered in human cells

The classic double helix has been joined by a four-stranded version that may play a role in cancer



Turn up the bass to scare birds away from planes

Subwoofers that blast out sounds too low to be heard by humans can keep birds out of busy air space, and prevent them colliding with planes



Earth may be crashing through dark matter walls

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Blinded by sun? Let your steering wheel guide you

A steering wheel that buzzes when drivers are dazzled by bright lights and drift from their lane could help curb accidents



NASA planet-hunter is injured and resting

The Kepler space telescope has put its search for alien Earths on hold while it recovers from a stressed reaction wheel



High-tech Dreamliner's wings clipped by battery trouble

Boeing's 787 Dreamliner is replete with cutting-edge technology. But problems with its complex systems now have the planes grounded around the world




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New Medifund Junior scheme set up






SINGAPORE: The Health Ministry will pump in an additional S$10 million over the next five years to help needy children with healthcare costs under a new scheme called Medifund Junior.

Children below 18 will be able to tap into this fund to help defray their healthcare costs.

With this new fund, there will now be a dedicated source of financial assistance for bills incurred by sick children from needy families.

The fund will also help defray costs for needy children diagnosed with congenital or neonatal conditions before 1 March 2013.

The government will also set up a Medisave account and deposit a one-off Medisave grant of S$3,000 over two tranches for all Singapore citizens born on or after 26 August 2012.

The move is to support Singaporean families in retaining continuous MediShield protection for their newborns.

- CNA/al



Read More..

3 Americans killed in Algeria






STORY HIGHLIGHTS


  • NEW: 7 Japanese are confirmed dead, 3 are unaccounted for, a Japanese minister says

  • NEW: An Algerian official says the gas plant will reopen and foreign workers will return

  • In addition to 37 confirmed dead, 5 hostages are unaccounted for, Algeria's leader says

  • The militants, who were of eight nationalities, came from northern Mali




(CNN) -- At least 37 hostages died in the terrorist seizure of a natural gas facility in eastern Algeria and the subsequent special forces assaults on it, the country's prime minister said Monday.


Five other hostages are missing from the In Amenas complex and could be dead, Prime Minister Abdul Malek Sallal said.


Before Sallal's statement, officials from other countries and companies that employed foreign workers at the sprawling plant had confirmed 29 hostage deaths.


Seven of the 37 confirmed dead haven't been identified yet, according to the prime minister. Those who have been identified include seven Japanese, six Filipinos, three Americans, three Britons and one Algerian, officials from those countries said.


Some 29 militants also died, while three were captured, Sallal said, according to the state-run Algerian Press Service.


The standoff ended Saturday, after four days, when Algerian special forces stormed the complex for the second time. The government said it did so because the militants were planning to blow up the installation and flee to neighboring Mali with hostages.










"If it exploded, it could have killed and destroyed anything within 5 kilometers or further," Sallal said.


Read more: Bloody Algeria hostage crisis ends after 'final' assault, officials say


Militant says Mali unrest spurred assault; others say it followed ample planning


The crisis began Wednesday when Islamist extremists in pickup trucks struck the natural gas complex some 50 kilometers (30 miles) west of the Libyan border, gathered the Westerners who worked there into a group and tied them up.


After taking over, the well-armed militants planted explosives throughout the complex, Sallal said. They came from eight countries: Algeria, Tunisia, Egypt, Mali, Niger, Canada and Mauritania.


Algeria's military talked with the militants, but their demands that prisoners in the North African nation be released were deemed unreasonable, according to the prime minister. The country's special forces waged the assaults to free the hostages and were backed by the Algerian Air Force.


Read more: Nations scramble to account for missing after Algeria hostage crisis


At one point, the militants tried to flee the compound in vehicles that carried explosives and three or four hostages as human shields, Sallal said. At least two of the vehicles flipped and exploded during the attempt, he said.


Sallal said the terrorists had entered the country from northern Mali, where Malian and French authorities are battling Islamist rebels.


One-eyed veteran Islamist fighter Moktar Belmoktar has claimed responsibility for the hostage-taking on behalf of his al Qaeda-linked group, according to Mauritania's Sahara Media news agency.


Belmokhtar said the attack was in retaliation for Algeria allowing France to use its airspace to battle Islamist militants in Mali. But regional analysts believe the operation was too sophisticated to have been planned so quickly, and Sallal said the hostage scheme had been hatched over months.


Algerian minister says gas plant will restart, foreign workers will return


The targeted gas facility is run by Algeria's state oil company, in cooperation with foreign firms such as Norway's Statoil and Britain's BP. Some 790 people worked there, including 134 foreign workers, Algeria's prime minister said.


Read more: Algerian forces seek 'peaceful' settlement of dramatic, deadly hostage crisis


British Prime Minister David Cameron said Monday the effort to evacuate workers is complete and that U.K. officials are now focused on bringing the bodies of slain British hostages back home.


Cameron praised Algerian forces for their work in ending the crisis, despite concerns from some nations earlier that the Algerians had unnecessarily put hostages at greater risk.


"This would have been a most-demanding task for security forces anywhere in the world, and we should acknowledge the resolve shown by the Algerians in undertaking it," the British leader said. "The responsibility for these deaths lies squarely with the terrorists."


Such Islamist militant activity is not new to Africa, including recent violence in Mali and Somalia.


Algeria's status as Africa's largest natural gas producer and a major supplier of the product to Europe heightens its importance to those who want to invest there. That interest is coupled with pressure to make sure foreign nationals, and their business ventures, are safe.


Energy and Mining Minister Youcef Yousfi, who a day earlier insisted Algeria can keep its gas facilities secure without foreign forces' help, said he believes the targeted gas facility will be back running "in the shortest possible time" and that foreign workers will soon return. Several foreign companies, including Statoil and BP, evacuated their workers from Algeria after the incident.


"I don't think that these workers have left definitively Algeria," Yousfi told reporters, according to the Algerian Press Service. "Maybe some left ... to reassure their families, but I want to ensure that no company or no worker permanently left the country."


Nations mourn dead, try to account for others


Here is a breakdown on the status of hostages from around the world who were involved in the crisis:


Colombia


Colombia's president said one of its citizens is presumed dead.


France


No known French hostages are unaccounted for, the defense ministry said.


A man identified as Yann Desjeux died after telling French newspaper Sud Ouest that he and 34 other hostages were treated well. It was unclear what led to his death.


Japan


Japanese Vice Foreign Minister Minoru Kiuchi and officials from JGC, a Yokohama-based engineering firm, saw and identified the bodies of seven Japanese citizens killed in the crisis, Chief Cabinet Secretary Yoshihide Suga announced late Monday.


Three Japanese remain unaccounted for, according to Suga.


Malaysia


Three hostages were on their way back home, state media reported. There is a "worrying possibility" that another is dead while a fifth is unaccounted for, the agency said.


Read more: Algeria attack may have link to Libya camps


Norway


Five Norwegians are missing, while eight are safe, according to Norwegian Prime Minister Jens Stoltenberg.


Philippines


Six Filipinos are confirmed dead and four are missing, the nation's foreign affairs ministry said. In addition, 16 Filipinos are alive and accounted for, according to a ministry spokesman.


Romania


One Romanian lost his life while four others were freed, the country's foreign ministry said.


United Kingdom


Three British citizens were killed, the Foreign Office said Sunday. Three other British nationals and a UK resident are also "believed dead," according to British officials. The Foreign Office confirmed the name of one slain hostage, Garry Barlow, in a statement Monday.


"Garry was a loving, devoted family man, he loved life and lived it to the full. He was very much loved by myself, his sons, mother and sister and the rest of his family and friends and will be greatly missed," the Foreign Office quoted his wife, Lorraine, as saying.


Twenty-two other Britons who were taken hostage have safely returned home.


United States


U.S. State Department spokesman Victoria Nuland on Monday said three Americans had been killed and identified them as Victor Lynn Lovelady, Gordon Lee Rowan, and Frederick Buttaccio, who had been previously identified.


Seven U.S. citizens survived the crisis, added Nuland, who declined to comment further citing privacy considerations.


Read more: Algeria attack may have link to Libya camps


CNN's Yoko Wakatsuki and Greg Botelho contributed to this report.






Read More..

Anticipating Obama's coming immigration push

(CBS News) MESA, Arizona - In his inaugural address Monday, President Obama touched only briefly on immigration reform. But in the next few weeks, he is expected to propose changes that would put millions of illegal immigrants on the path toward U.S. citizenship.

It could be one of the biggest challenges in his second term.

"We need this president to push as hard as he can, because Latinos care about immigration and the election showed it," said Erika Andiola, a well-known immigrant rights activist in Arizona. "Our families can no longer be separated."

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She crossed the border illegally from Mexico with her mother when she was 11 years old. She was asked what she would say to people who point out she entered illegally.

"Give us a chance to be in the country -- to give back to the country. I think a lot of us have a lot to contribute," Andiola said.

President Obama's deferred deportation program allows those who came illegally as children to work or study in the U.S.

"It would definitely be a dream come true if I was to become a citizen," Andiola said.


Erika Andiola

Erika Andiola, right, and her mother


/

CBS News

She recently lived every illegal immigrant's nightmare. Federal agents took her mother and brother from their home to be deported. Andiola jumped into activist mode. She posted a YouTube video about her experience.

Word went out on Twitter and Facebook.

"Just one organization was able to get 18,000 petitions in a matter of 12 hours.," Andiola said.

She even got members of Congress to call immigration authorities. Her brother and mother were released within 20 hours. Yet, Andiola points out, a record number of undocumented immigrants - almost 410,000 - were deported last year.

"This is why we need immigration reform," Andiola said. "I think it has to happen."

Hispanic political power helped release her mother -- helped elect a president -- and she's convinced it will forge a path to citizenship for millions like her and her mother.

Read More..

Live Blog: First Dance of Second Term


Four years and one day after President Obama first took his first oath of office, America is once again celebrating his Inauguration. This time the schedule includes performances by Beyonce and Katy Perry, a parade with more than 2,000 members of the military and two Inaugural balls.


Refresh here for updates throughout the day.


Tune in to the ABC News.com Live page on Monday morning starting at 9:30 a.m. EST for all-day live streaming video coverage of Inauguration 2013: Barack Obama. Live coverage will also be available on the ABC News iPad App and mobile devices.


Read Obama’s second Inaugural address here.


All times are in Eastern Standard Time.



9:22 p.m. – Photo: Obama and Michelle’s First (Second Inaugural) Dance 


michelle red dress inauguration tk ssm 130121 wblog LIVE UPDATES: Inauguration Day 2013

President Barack Obama and First Lady Michelle Obama dance together at the Walter E. Washington Convention Center, Jan. 21, 2013, in Washington, DC. (Jewel Samad/AFP/Getty Images)


9:06 p.m. – Michelle’s Dress


ABC’s Mary Bruce reports:


The First Lady is wearing a custom Jason Wu ruby colored chiffon and velvet gown with a handmade diamond embellished ring by jewelry designer Kimberly McDonald. She is wearing shoes designed by Jimmy Choo. At the end of the Inaugural festivities, the outfit and accompanying accessories will go to the National Archives.


The President and First Lady are dancing to Al Green’s “Let’s Stay Together,” performed by Jennifer Hudson.


The Vice President and Dr. Biden will dance to Ray Charles’ “I Can’t Stop Loving You,” performed by Jamie Foxx.


Hudson and Foxx will perform the first dance song at each of the first and second families’ stops – in the Ballroom for the Commander-in-Chief’s Ball and on both floors of The Inaugural Ball.


9:00 p.mObama Thanks Soldiers at Commander in Chief’s Ball


The president and Michelle Obama made their first stop of the night at the Commander in Chief’s ball, where President Obama thanked military servicemembers in the audience as he spoke.


“I have no greater honor than being your commander in chief. It’s because of you that with honor we were able to end the war in Iraq, because of you that we delivered justice to Osama bin Laden, because of you that it’s even possible to give Afghans a chance to determine their own destiny,” Obama said.


A TV screen to Obama’s right showed soldiers stationed in Kandahar, Afghanistan. Privates and master sergeants congratulated him on his inauguration.


“Every single day we are thinking of you,” Obama told them in response. “When you get back home, you’re gonna be greeted by a grateful nation, and you’re gonna be on our minds tonight and every single night until our mission in Afghanistan is complete.”


8:32 p.m. – The Balls are Underway – Get the live stream at abcn.ws/live


6:35 p.m. – Welcome to Twitter, Michelle’s Bangs


We knew it was coming. Someone created a Twitter account called @FirstLadysBangs.


Withing hours of its entry into the world, the Twitter character had considered and shot down a run against Donald Trump’s hair in 2016.


Sound a little crazy? Blame it on super long parade fatigue.



5:42 p.m. – The Cheese Stands Alone


The ladies of the Obama clan have left the Presidential Reviewing Stand. The president remains there to watch the rest of the parade, including a group of uni-cyclists from Maine called the “Gym Dandies.”



5:28 p.m. – Obama Inauguration: Who’s Who?


Who were those people sitting behind the president this morning anyway? Click the photo below to see an infographic with a guide to Obama’s family, colleagues and dignitaries.


ap inauguration ip 005 130121 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Scott Andrews/AP Photo)



5:22 p.m. – Biden 2016?


Vice President Joe Biden got very friendly with members of the crowd watching the inaugural parade, prompting some to wonder if this isn’t a prelude to his own presidential run.





4:55 p.m. – POTUS on His Blackberry Before the Parade


abc obama blackberry tk 130121 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Obtained by ABC News)


It may be a day-long celebration for President Obama, but that doesn’t mean he has left work at the office.


Just before members of the military began streaming by the Presidential Reviewing Stand as part of the inaugural parade, Obama could be seen working on what looks like his specially-secured Blackberry.


Beside him, Sasha and Malia whipped out their iPhones, taking photos of their mother and interrupting their father to make him pose with the first lady. The first family had removed their coats, thanks to heat inside the reviewing stand.


And it was also clear President Obama was chewing gum as he head-bobbed along to the marching bands. Today more than ever he looked like Obama: the gum-chewing, Blackberry-checking president of the people.


What’s not clear – who emails the president on inauguration day? And was it Nicorette gum?



4:30 p.m. – Wrapping Up the Route


ap inauguration ip 013 130121 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Charles Dharapak/AP Photo)


ABC’s Devin Dwyer reports the President, the first lady, the Vice President and Dr. Biden will soon make their way to the reviewing stand on Pennsylvania Ave. where they will be joined by Congressional leaders, Supreme Court Justices, governors, the Joint Chiefs and White House staff as well as area elementary school students and some of the Tuskegee Airmen and their families, according to the White House.



4:00 p.m. – Obama, Roberts Sign King Bible


ABC’s Avery Miller reports President Obama and Supreme Court Chief Justice John Roberts signed Martin Luther King, Jr.’s Bible today, at the request of the family.


In his life time, it was King’s “traveling Bible,” according to the Presidential Inaugural Committee.


“An avid reader who was constantly on the road, Dr. King typically traveled with a selection of books that included this Bible,” the PIC wrote in a statement about the Bible written when they announced Obama would use it in his ceremony. “It was used for inspiration and preparing sermons and speeches, including during Dr. King’s time as pastor of Dexter Avenue Baptist Church in Montgomery, Alabama.”


Read more about President Obama’s choice of Bibles here.



3:56 p.m. – Justice Scalia and the Mystery of the Funny Hat


Michelle Obama wasn’t the only one drawing eyes with her fashion choices at the inaugural ceremonies today. Many on Twitter – including Sen. Claire McCaskill, D-Mo., – remarked on Associate Justice Antonin Scalia’s choice of headgear during President Obama’s swearing-in.


Some compared it to Aretha Franklin’s extravagant hat at the 2009 inauguration. Others simply wondered where it came from.


To find that answer, ABC’s Sarah Parnass spoke with Scalia’s former clerk, Kevin Walsh.


Walsh, who now teaches at University of Richmond School of Law, said the association of Catholic lawyers to which he belongs, St. Thomas More Society of Richmond Va., presented Scalia with the hat in 2010.


The hat is a replica of one worn by St. Thomas More in his most iconic portrait, done by Hans Holbein, according to Walsh.


When giving Justice Scalia the hat, the members of the St. Thomas More Society thought it would be a nice memento. “If nothing else it would be suitable for university functions,” Scalia said.


Walsh said the significance of Scalia’s wearing the hat likely doesn’t go beyond function. In the past, Scalia has worn a skull cap, much like the one Justice Breyer sported today. But the skull cap doesn’t have earflaps – the More hat does.


“That one’s warmer,” Walsh said, comparing the hat Scalia wore today with the one he wore to the 2009 inauguration. “I’d say it’s more functional.”


ABC’s Bob Murphy adds this historical background:


Thomas More was the Lord Chancellor or Chief Legal Officer of England when Henry VIII was King. He famously lost his head (the one the hat was made for) rather than reinterpret the laws of divorce and allow the King to dispatch his Queen. He is a hero to the Catholic legal community for his commitment to moral and legal authority over the whim of the chief temporal power.


The ultraconservative Catholic jurist may or may not be making a statement but the significance is interesting.





3:39 p.m. – Inauguration Day in Pictures


Click the picture below for a slideshow of some of the 2013 inauguration’s most memorable moments so far.


ap 09 inauguration obama wm nt 13021 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Jonathan Ernst-Pool/AP Photo)



3:33 p.m. – Obama Pauses for Final Glimpse of Fans


ABC’s Devin Dwyer reports:


After a bruising campaign, and unusually contentious post-election period, President Obama savored his second and final Inauguration Day as a brief respite from political storms and celebratory moment for his hundreds of thousands of adoring supporters.


As he walked off the inaugural platform on the west front of the U.S. Capitol, Obama turned and paused to look out at the crowd on the National Mall, even as his family and other guests continued ahead without him.


“I want to take a look one more time,” Obama was heard saying. “I’m not going to see this again.”


Read more on that poignant moment with the president here.



3:22 p.m. – Obama Makes History Citing Gay Rights in Inaugural Address


ABC’s Shushannah Walshe reports:


President Obama made history in his inaugural address today mentioning the word “gay” and the issue of gay rights for the first time in a speech at the presidential swearing in.


“Our journey is not complete until our gay brothers and sisters are treated like anyone else under the law for if we are truly created equal, then surely the love we commit to one another must be equal as well,” Obama said in his address on the Capitol steps after his swearing in.


Obama also mentioned the word Stonewall when citing milestones of the civil right struggle. It was a reference to a riot and subsequent protests over a police raid in June 1969 of the Stonewall Inn, a gay bar in New York City’s Greenwich Village. The president mentioned it along with the first women’s rights convention held in Seneca Falls, N.Y., in 1848 and the civil rights march in Selma, Ala., in 1965.


“We, the people, declare today that the most evident of truths – that all of us are created equal – is the star that guides us still; just as it guided our forebears through Seneca Falls, and Selma, and Stonewall,” Obama said.


Brian Ellner who led the successful campaign to make same sex marriage legal in New York state called the speech “historic.”


Read more from Walshe here.


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3:12 p.m. –  Obama Sticks to His Script in Second Inaugural Address


ABC News’ Michael Falcone reports:


By their very nature, the texts of presidential inaugural addresses become historical documents as soon as they are delivered. Obama’s speech, like all the others before, will be scrutinized for years to come.


So, how closely did President Obama, who is known for his oratorical prowess, hew to the prepared text of his remarks? With the exception of a few minor words,


It turns out he stuck almost exactly to the script.


“We must harness new ideas and technology” became “So we must harness…” and “Let each of us now embrace, with solemn duty and awesome joy, what is our lasting birthright” ended up as “Let us, each of us, now embrace…” He sprinkled in an extra “and” at the beginning of one paragraph and turned a “that is” into “that’s.”


Otherwise, the president delivered the speech he had in front of him with almost no changes.


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2:26 p.m. – Tell the President What You Want


Whether you voted for him or not, tell President Obama what you’d most like to see him tackle in his second term and why.


Upload a video or photo, or send your comments telling the president what is most important to you in the next four years.


The best submissions may be featured today on ABCNews.com.


Click the photo below to see how you can participate.


abc tell the president ll 130116 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: ABC News Photo Illustration)


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2:11 p.m. – Obama Address References Civil Rights, Gay Marriage, Immigration


Univision’s Jordan Fabian reports:


Obama, the nation’s first black president, delivered his address on Martin Luther King, Jr. Day and drew strong parallels between the civil rights battles of King’s generation to the social issues facing today. Perhaps most notable was Obama’s reference to gay rights, believed to be a first for a presidential inaugural address.


“Our journey is not complete until our gay brothers and sisters are treated like anyone else under the law,” he said. “For if we are truly created equal, then surely the love we commit to one another must be equal as well.”


The president also made a forceful statement in support of comprehensive immigration reform, a campaign pledge from 2008 that remains unfulfilled. Obama has repeatedly pledged to make it one of his top legislative priorities this year.


“Our journey is not complete until we find a better way to welcome the striving, hopeful immigrants who still see America as a land of opportunity; until bright young students and engineers are enlisted in our workforce rather than expelled from our country,” he said.


Read more from Fabian here.




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2:05 p.m. – Obama’s Inaugural Declaration: ‘Our Time’ for Changing Nation


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(Image Credit: Win McNamee/AP Photo)


Analysis by ABC’s Rick Klein:


President Obama used a brief pause in the partisan warfare that’s scarred his time in office to return to the ideals of the Declaration of Independence, with his own declaration of urgency and a call to action that reflects shared sacrifice and responsibility.


This was no centrist conciliator. It was the speech of a committed, unapologetic progressive, an Obama doctrine for domestic policy that included concrete commitments in areas he made little progress on over his first four years. Above all, he was speaking to a changing America – the nation that propelled him to a second term, and whose voices he will need to channel to be effective over the next four years.


“My fellow Americans, we are made for this moment, and we will seize it – so long as we seize it together,” the president declared.


Read more on what Obama meant and what opportunities he sees going forward here.



1:30 p.m. – More on Inaugural Poet Richard Blanco


Univision’s Jordan Fabian reports:


There has not been another inaugural poet like Richard Blanco.


Out of the five people selected to read an original poem at a presidential inauguration, the 44-year-old Blanco is the first Latino, first gay man, and youngest person to serve the role. The presidential inaugural committee officially announced the choice of Blanco, the son of Cuban exiles, last Wednesday.


Read more from Fabian here.


Blanco wrote the poem he read, called “One Today,” in the past 11 days. It included several references to America’s workers, including the following:


One sky: since the Appalachians and Sierras claimed
their majesty, and the Mississippi and Colorado worked
their way to the sea. Thank the work of our hands:
weaving steel into bridges, finishing one more report
for the boss on time, stitching another wound
or uniform, the first brush stroke on a portrait,
or the last floor on the Freedom Tower
jutting into a sky that yields to our resilience.


Read the full poem here.


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1:24 p.m. – Sen. McCaskill Calls Out SCOTUS Hats





1:24 p.m. – Terry Moran: Inauguration Fits ‘Next America’


In response to remarks about Obama’s reference to gay marriage, Nightline’s Terry Moran analyzes the firsts of this inauguration:


Has Spanish been spoken before? Has there ever been a bigger crowd for a second inaugural?


To me, Obama’s speech, this crowd, the whole program, seemed deliberately designed to confirm the “next America”–younger, more diverse, more non-native, socially liberal–as the source of authority, even legitimacy in the nation going forward.


That’s what the election was really about, deep down. And the feeling out here seems more than the usual inaugural victory lap of the party in power. It seems cultural–and historic. It’s their moment. And so is tomorrow–not in a partisan sense. In a factual one.


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1:14 p.m. – Inaugural Performances


Kelly Clarkson, James Taylor and Beyonce sang during the inaugural ceremonies this year.




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1:09 p.m. – What’s On the Menu?


President Obama now joins members of Congress and the Supreme Court for the inaugural luncheon.


ABC’s Devin Dwyer reports the inaugural luncheon menu from the JCC:


First Course: Steamed lobster with New England chowder


Wine: Anthony Road Winery, Fox Run Vineyards & Newt Red Cellars, Tierce 2010 Dry Riesling, Finger Lakes, N.Y.


Second Course: Hickory grilled bison with wild huckleberry reduction and red potato horseradish cake


Wine: Bedell Cellars, 2009 Merlot, North Fork, Long Island, N.Y.


Third Course: Hudson Valley apple pie, sour cream ice cream, aged cheese and honey


Wine: Korbel Natural, Special Inaugural Cuvée Champagne, Calif.


NOTE the New York food/wine: Water in the holding rooms is to be Saratoga Springs (a NY label), per a PIC official. And the wines to be served at the inaugural luncheon are from New York vineyards —- all thanks to NY Sen. Chuck Schumer, who chairs the Joint Congressional Committee on Inaugural Ceremonies


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12:46 p.m. – Timing Is Everything: Chris Christie Makes Announcements Minutes Before Obama’s Speech


ABC News’ Michael Falcone reports:


During the very same hour of President Obama’s second inauguration, New Jersey Gov. Chris Christie, who is often mentioned as a potential 2016 Republican presidential contender, sent out two separate announcements.


The first from his gubernatorial campaign: “Governor Chris Christie will be visiting the Hilton Newark Airport on Tuesday morning to accept the second major endorsement of his campaign.” (The campaign did not provide information about who will be endorsing him). And the second, a statement commemorating Dr. Martin Luther King, Jr. Day. (Christie, who praised President Obama’s efforts in the wake of Hurricane Sandy, which devastated portions of coastal New Jersey, did not mention the president’s inauguration):


“Dr. King was the paradigm of strength in triumphing over adversity and racial injustice to achieve what seemed impossible to so many for so long. His legacy stands as an eternal reminder of his sacrifice and the progress he achieved and which we are obliged to protect for every citizen of our state and nation. I join New Jerseyans in honoring Dr. King’s life and work and his uncompromising commitment to peacefully working toward freedom and equality for all Americans,” Christie said in the statement.


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12:16 p.m. – Richard Blanco Delivers Inauguration Poem


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12:09 p.m. – Obama Gives Shout Out to Same-Sex Couples in Inaugural Address


In his inaugural address today, President Obama called for treating same-sex couples equal under the law. ABC News’ Arlette Saenz reports:


Of the group of 215 members in the Lesbian and Gay Band Association marching in the inaugural parade, four couples are legally married.


Leslie Becker and Lindsay Famula of Hackensack, N.J., met when Famula joined the band in 2006, and the two women, who are both percussionists, were married in May.


“It’s validation. The fact that we have been denied this right for so long when really all we want to do is be seen in the government as a couple means a lot,” Becker said. “‘Don’t ask, don’t tell’ was repealed. We’re making big advancements in civil rights for gay couples, and it means a big deal to be one of the few married couples to march in this parade.”


New Jersey has allowed civil unions since 2006, but New Jersey Gov. Chris Christie vetoed a same-sex marriage bill in February.


Becker played at President Bill Clinton’s inauguration in 1997, but the LGBA only played on the side of the parade. During President Obama’s first inauguration in 2009, the LGBA, including Becker, marched in the actual parade.


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11:56 a.m. – Hundreds of Thousands Turn Out for Inauguration


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(Image Credit: Joe Raedle/Getty Images)


As of 11:00 a.m., Washington Metro Area Transit Authority reported 308,000 people used their rail service this morning. Metro was preparing last week for an estimated 600,000 to 800,000 people to come to D.C. for the events.


In 2009, 1.8 million people gathered to welcome in Obama’s first term.


Around 11:30 a.m., the U.S. Park Police released a statement about the crowding: “The National Mall is now full and closed. All visitors not on the Mall should proceed to the overflow area at the Washington Monument.”



11:50 a.m. – Obama Takes Oath for Fourth Time


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(Image Credit: ABC NEWS)


With his hand on two Bibles held by his two daughters, President Barack Obama took the inaugural oath for a fourth time. Supreme Court Chief Justice John Roberts administered the oath.



11:38 a.m. – Evers-Williams Delivers Invocation





11:33 a.m. – ABC Correspondent Tweets from Pakistan




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11:30 a.m. – Ryan Congratulates Obama


ABC’s Elizabeth Hartfield reports:


No word from Mitt Romney, but his running mate, Rep. Paul Ryan sent out a congrats to President Obama.




Ryan posted a longer congratulations on his Facebook page.


I congratulate President Obama on his inauguration, and I join the country in celebrating this American tradition.


The president and I were political opponents. We had strong disagreements over the direction of the country—as we still do now. But today, we put those disagreements aside. Today, we remember what we share in common.


We serve the same country, one that is still in need of repair—and is still the freest on earth. We serve alongside men and women from both parties, who govern in good faith and good will. Finally, we serve the same people, who have honored us with their charge.


We may disagree on matters of policy. But today we remember why we take those matters so seriously—because we seek the public good. It’s our highest duty—one that we share—and one for which we’re grateful.


I’m happy to mark this historic occasion—for the president and for the country. And I look forward to tackling the big challenges ahead.


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11:20 a.m. – A Look Back at Obama’s First Inaugural Address


ABC’s Elizabeth Hartfield reports:


As Obama’s prepares to give his second inaugural address, a look back at the first: Obama’s speech in 2009 ran 2,395 words.


According to a handy word count breakdown from the Wall Street Journal, Obama used the word “people” eight times, the word “God” five times, and the word “government” four times. We can expect that those words will pop up again in today’s speech, as the president is expected to talk about unity and finding common ground among our nation’s leaders.


A word he only uttered once in 2009, that we might expect him to bring up again more this time- “war” – as the president looks back on the drawdown of America’s military presence in Iraq, and ahead to the drawdown in Afghanistan.


Today’s speech is expected to be shorter than his speech four years ago – but by how much will remain to be seen. The high bar of second inauguration speeches is Abraham Lincoln’s address in 1965- where he managed to say a lot, in just a few words- 698 to be exact.


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11:16 a.m. – Obama Enters Arena


President Obama has entered the Capitol. Vice President Joe Biden and House Minority Leader Nancy Pelosi are close behind.


ABC’s Michael Falcone points out President Obama will be getting down to business shortly after he delivers his second inaugural address, officially submitting the names of his nominees for the posts of CIA Director, Secretary of Defense, Secretary of State and Secretary of the Treasury, according to a White House official.


Today, at the Capitol the President will be signing:


1. A Proclamation to commemorate the inauguration titled, “National Day of Hope and Resolve, 2013.”
2. Four Nominations:
a. John Owen Brennan to be Director of the CIA
b. Charles Timothy Hagel to be Secretary of Defense
c. John Forbes Kerry to be Secretary of State
d. Jacob J. Lew to be Secretary of the Treasury


ABC’s Devin Dwyer notes that four years ago, Obama signed a similar proclamation and nominations to the Senate. This occurs in the President’s Room, just off the Senate chamber, immediately following the address.


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11:15 a.m. –




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11:08 a.m. – The Biden Family Bible


ap joe biden inauguration bible ll 130121 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Carolyn Kaster/AP Photo)


A large Bible being carried in is attracting some attention for its size. The Bible belongs to the Biden family, and it’s the one Vice President Joe Biden will use to swear his oath of office, as he did four years ago.


The 120-year-old book has a Celtic cross on the front and has been passed down through the Biden clan. It is 5 inches thick, according to the Presidential Inaugural Committee.


Biden also used it Sunday in his private swearing-in ceremony at the Naval Observatory.


ap inaugural joe biden jt 130120 wblog LIVE UPDATES: Inauguration Day 2013

Carolyn Kaster/AP Photo


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11:04 a.m. – Powell Slams GOP’s ‘Idiot Presentations’


ABC’s Michael Falcone reports:


In an interview with ABC’s Diane Sawyer and George Stephanopoulos during ABC’s special inauguration day coverage this morning, former Secretary of State Colin Powell lashed out at people in the Republican Party who spent the last four years spreading “birther nonsense” and other “things that demonize the president,” calling on GOP leaders to denounce such talk — publicly.


“Republicans have to stop buying into things that demonize the president. I mean, why aren’t Republican leaders shouting out about all this birther nonsense and all these other things? They should speak out. This is the kind of intolerance that I’ve been talking about where these idiot presentations continue to be made and you don’t see the senior leadership of the party say, ‘No, that’s wrong.’ In fact, sometimes by not speaking out, they’re encouraging it. And the base keeps buying the stuff.


“And it’s killing the base of the party. I mean, 26 percent favorability rating for the party right now. It ought to be telling them something. So, instead of attacking me or whoever speaks like I do, look in the mirror and realize, ‘How are we going to win the next election?”


Read more from Falcone here.


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10:59 a.m. – Former President Carter Enters


Thirty-ninth President Jimmy Carter and his wife, Rosalynn, entered the Capitol to applause from the crowd. The former president shook hands and exchanged greetings with others awaiting President Obama. Carter is 88 years old and one of two former presidents expected at today’s ceremony.


The second, former President Bill Clinton, entered moments later with Sec. of State Hillary Clinton by his side.


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10:56 a.m. – How to Crash a Party


Not invited to any of the official inaugural shindigs? No sweat.


ABC’s Chris Good got the scoop on how to sneak into the festivities from Fred Karger, former 2012 Republican presidential candidate and self-proclaimed party-crasher extraordinaire.


“Karger says he has crashed an inauguration party before, plus the Oscars and Fashion Week. He has fooled rope-line workers, he says, and even the Secret Service,” Good reports.


“He twice found himself onstage at the Oscars, he says, once singing the final number alongside Liza Minnelli.”


A few of Karger’s tips: call ahead under a fake name, blend in with the entourage and don’t look back. Find all of Karger’s tips and more reporting from Chris Good here.


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10:52 a.m. – Presidential Limo: Belly of the Beast


President Obama got an upgraded presidential limo when he took office four years ago.


Pierre Thomas got an exclusive look at the unveiling back then. Take a look:


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10:41 a.m. – POTUS Departs


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(Image Credit: DC Vote)


President Obama has left the White House and entered his motorcade, on the way to the Capitol.


The president’s limo is sporting special plates today, in support of the D.C. statehood movement. Read more about those plates here.


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10:39 a.m. – First Lady and Vice President on Their Way


First lady Michelle Obama left the White House, followed shortly by Vice President Joe Biden.


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10:34 a.m. – Obamas Leave White House


President Obama’s daughters, Sasha and Malia, left the White House in their pink and purple coats just a moment ago. They’re headed for the Capitol, where they will watch their father take the presidential oath for the fourth time.


They were followed minutes later by a band of Marines, then by Dr. Jill Biden, Vice President Joe Biden’s wife.


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10:31 a.m. – Events Heating Up


Members of Congress can be seen streaming into the Capitol. The inaugural pre-show began at 9:30 a.m., but Sen. Chuck Schumer, D-N.Y., won’t begin introducing the president for another hour.


Across the National Mall, attendees are waving American flags, in a sea of red, white and blue.


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10:17 a.m. – Presidential Imperfections


It’s a not-so-secret understanding that even the most well-respected president’s weren’t perfect. Turns out neither were their inaugural ceremonies.


Find the funniest and quirkiest inaugural slip ups here.


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9:58 a.m. – How Do You Spell the Event of the Day?


js inauguration  spelling wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Joanna Stern / ABC News)


ABC’s Joanna Stern reports:


Nope, it’s not inaugration. Not inaguration either. Inaugiration? Not correct. And it’s definitely not innoguration or anauguration.


Inauguration. That’s the correct spelling of the word for that big event today, at which, you know, the president officially becomes the president again.


But don’t be embarrassed if you spelled it incorrectly. It turns out it’s a pretty popular thing to do.


Over 2,500 people have tweeted about the “inaguration,” according to Topsy, which tracks tweets on Twitter. Topsy says 866 of those tweets have been in the last 30 days. “Inaugration” has been used in over 700 tweets.


Read more from Stern on the many misspellings of this historic event here.


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9:42 a.m. – Obamas on the Move


The Obama family has left church services at St. John’s Episcopal Church and headed back to the White House.


To see where the president will go next, check out ABC’s interactive map here.


Pastor Andy Stanley from the North Point Community Church in Alpharetta Georgia delivered the sermon, according to pool reports, calling the president “pastor in chief.”




This tweet from the president posted while the Obama family was still in church.




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9:15 a.m. – Obama’s View


ABC’s Jonathan Karl is on the platform at the West Front of the Capitol Building where Obama will give his inaugural address later today. He’s got the best view of the crowds, which won’t come close to the 1.8 million of four years ago, but which already number hundreds of thousands.




9:11 a.m. – Members of Congress Honor MLK on Twitter


Today America remembers the legacy of another great leader: Martin Luther King, Jr. Members of the House and Senate are taking to Twitter to express their admiration for King this morning.







9:04 a.m. – On the Ground with Good Morning America.



  Back to top 9:03 a.m. – Best and Worst Inaugural Addresses


gty Abraham Lincoln nt 120918 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: Getty Images)


ABC’s Chris Good reports on the best and worst inaugural speeches of all time: Inaugural addresses, it is said, are usually not very good. Most have been long forgotten, and historians themselves point to few as memorable. It’s not entirely clear why, but the moment might have something to do with it. Book-ending divisive national campaigns, inaugural addresses offer token unity sentiments, hopefulness but not always specific hopes, and even some good ones sound myopic. “Most inaugural addresses are not remembered,” said Princeton University professor and noted presidential historian Eric Foner. “Grover Cleveland? I have no idea what he said in his.” “I have actually read every single inaugural, and it was a really boring experience,” said Robert Lehrman, a former speechwriter for vice president Al Gore, who now teaches the craft at American University in Washington. “Most of the speeches are terrible. Even the ones we remember, I don’t think there is any reporter working anywhere that couldn’t write language as crisp or concrete as the majority of them.” Read the rest of the worst and the best here. Back to top 8:56 a.m. – Outfits of the Inauguration: Obama Style ABC’s Mary Bruce reports: The President, First Lady, in a dark blue jacket, and daughters Malia, in a pink overcoat, and Sasha, in dark purple, arrived just after 8:40 a.m. at St. John’s Episcopal Church for morning services. The First Lady is wearing a navy Thom Browne coat and dress. The fabric was developed based on the style of a man’s silk tie. The belt she is wearing is from J.Crew and her earrings are designed by Cathy Waterman. She is also wearing J.Crew shoes. At the end of the Inaugural festivities, the outfit and accompanying accessories will go to the National Archives. Malia Obama is wearing a J.Crew ensemble. Sasha Obama is wearing a Kate Spade coat and dress. The Bidens arrived moments later. Back to top 8:47 a.m. – Tailor to the Presidents: Republicans Dress Better



Back to top 8:45 a.m. – Great American QuotesInaugural addresses are an opportunity for presidents on the nation’s front lawn – a place that Americans come to in turns inaugurate their leaders, protest their government and mourn their dead – to place a marker for their legacy. There have been some weighty and remarkable things said as presidents took the oath of office looking down on the Mall and also, from nearby, as other Americans have looked up and let their voices be heard at gatherings as varied as the March on Washington and the Promise Keepers. What can Barack Obama say, come Monday, as he begins a second term with lower expectations and less inspiration, to place himself on this list of great American words? Click below for an interactive look at the competition:


inauguration infographic 640x360 wblog LIVE UPDATES: Inauguration Day 2013

(Image Credit: ABC News: Ma'ayan Rosenzweig)


Back to top 8:38 a.m. – Aretha Franklin’s Hat Makes a Comeback



  Back to top 8:22 a.m. – Martha Raddatz: Women Rule




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8:08 a.m. – Eva Longoria Wakes Up to with the White House




F schedule of events REV 20130117 update 2 LIVE UPDATES: Inauguration Day 2013


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Curated by ABC’s Z. Byron Wolf and Sarah Parnass

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Quadruple DNA helix discovered in human cells








































Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.













Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.












The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.












Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.












"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.











Tagged with antibodies













Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.












This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.












"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.












"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.












Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.












Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548


















































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