Liver cancer survival time tripled by virus



































The virus used in the vaccine that helped eradicate smallpox is now working its magic on liver cancer. A genetically engineered version of the vaccinia virus has trebled the average survival time of people with a severe form of liver cancer, with only mild, flu-like side effects.












Thirty people with hepatocellular carcinoma received three doses of the modified virus – code-named JX-594 – directly into their liver tumour over one month. Half the volunteers received a low dose of the virus, the other half a high dose. Members of the low and high-dose groups subsequently survived for, on average, 6.7 and 14.1 months respectively. By contrast, trials several years ago showed that sorafenib, the best existing medication for this cancer, prolonged life by only three months.












Two of the patients on the highest viral dose were still alive more than two years after the treatment. "It's a very substantial survival benefit," says Laurent Fischer, president of Jennerex, the company in San Francisco developing the treatment under the trade name Pexa-Vec.












Besides shrinking the primary tumour, the virus was able to spread to and shrink any secondary tumours outside the liver. "Some tumours disappeared completely, and most showed partial destruction on MRI scans," says David Kirn, head of the study at Jennerex. Moreover, the destruction was equally dramatic in the primary and secondary tumours.












"This clinical trial is an exciting step forward to help find a new way of treating cancers," says Alan Melcher of the University of Leeds, UK, who was not involved in the study. "It helps demonstrate the cancer-fighting potential of viruses, which have relatively few side effects compared with traditional chemo or radiotherapy," he says. "If it proves effective in larger trials, it could be available to patients within five years."












The fact that the virus appears able to spread to secondary tumours suggests that simply injecting the virus into the bloodstream may be effective. A trial to compare this treatment with injecting the virus directly into a tumour is under way.











Targeted at cancer













The virus has had a gene coding for an enzyme called thymidine kinase snipped out. The enzyme enables the virus to recognise and infect dividing cells. By removing the gene, the virus's developers have reduced the likelihood of healthy dividing cells being infected.












Instead, the virus exclusively attacks cancerous tissue, by targeting two genes that have increased activity in tumour cells. One genes is associated with an epidermal growth factor receptor, which stimulates the cancer to grow. The other is associated with a vascular endothelial growth factor, which enables the cancer to recruit its own blood supply. The virus reduces the activity of both genes, causing the infected cancer cell to wither and die.












What's more, the virus carries extra genes to prod the body's own immune system into action against the cancer. One produces granulocyte colony stimulating factor, a protein that encourages production of extra white blood cells at sites of infection. The other produces a protein not naturally found in humans, called Lac-Z, that earmarks infected cells for destruction.











Fischer says that to date, more than 200 people have received the virus, which has also shown promise against other types of cancer, including those of the kidney and skin. But he warns that not everyone sees a benefit. "We know why patients respond, but not why they don't," he says.













Journal reference: Nature Medicine, DOI: 10.1038/nm.3089


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Adele wins best pop solo performance Grammy






LOS ANGELES: British songstress Adele won the Grammy for best pop solo performance, the first award handed out during the main event on the music industry's biggest night of the year.

The 24-year-old singer, who swept the board with six Grammys at last year's awards show, took the prize for a live rendition of her hit "Set Fire to the Rain."

"My good luck charm, J-Lo," she said as she accepted the award from Jennifer Lopez and Pitbull. "This is amazing. I wanted to come and be part of the night. I loved it last year, obviously," she added.

Last year she won best song, best record, best album for her breakthrough "21," best short video, best pop album and best pop artist, winning all six categories in which she was nominated.

Indie pop band fun. won best song for "We Are Young," one of six categories in which they were nominated at music's biggest awards show.

The New York group are also shortlisted for the key categories of best record, best album and best new artist at the 55th Grammys Awards.

- AFP/ir



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Almost famous: See celebs' early roles








By Henry Hanks, CNN


updated 5:05 PM EST, Thu February 7, 2013





















Stars who started out like GoDaddy's geek


Jesse Heiman


Sylvester Stallone


John Travolta


Keanu Reeves


Courtney Cox


Matt LeBlanc


Tina Fey


Rainn Wilson


Megan Fox


Dean Winters















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Tornado rips through Miss., causes major damage

HATTIESBURG, Miss. An apparent tornado tore through Hattiesburg on Sunday as part of a wave of severe storms that downed trees, damaged buildings and caused at least several injuries.

The twister traveled down one of Hattiesburg's main streets and caused what officials described as major damage, officials said, hitting several buildings on the campus of the University of Southern Mississippi. Kyle Hopkins, emergency operations director for surrounding Forrest County, said officials hadn't confirmed injuries. There were reports of several people hurt elsewhere in the state.

"We had a tornado touch down. We have a lot of damage," Hopkins said.

The university released a statement saying that several buildings had been damaged but that no injuries were reported. Campus police have declared a state of emergency and asked anyone not on campus to stay away.

Video by CBS affiliate WHLT-TV shows the heavy damage to the university, including busted windows, wood panels strewn on the lawn and fallen fences.

The storm overturned and damaged vehicles and threw debris around parts of the campus.

To the west, Marion County emergency director Aaron Greer says three injuries have been reported in the community of Pickwick, about seven miles south of Columbia. He says two people were taken to hospitals, but the third didn't have the injury examined.

Greer says one mobile home was destroyed, three other structures have major damage and several have minor damage.

National Weather Service meteorologist Joanne Culin says there have also been reports of injuries in Marion County.

Nasty weather has settled in on much of Louisiana and Mississippi, including tornado or flash flood watches.

The National Weather Service says bad weather is likely to stretch into Fat Tuesday in southeast Louisiana. Jefferson Parish has canceled a Monday night parade.

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$1M Reward for Capture of Fugitive Ex-Cop Dorner













A $1 million reward was offered today for information leading to the arrest of Christopher Dorner, as authorities in Big Bear, Calif., scaled back their search for the disgruntled ex-cop, who is suspected in three revenge killings.


"This is the largest local reward ever offered, to our knowledge," Los Angeles Police Chief Charlie Beck said at a news conference today. "This is an act of domestic terrorism. This is a man who has targeted those that we entrust to protect the public. His actions cannot go unanswered."


The money for the reward was pooled by businesses, government, local law enforcement leaders and individual donors, Beck said.



PHOTOS: Former LAPD Officer Suspected in Shootings


The reward comes on the fourth day of a manhunt for Dorner, who has left Southern California on edge after he allegedly went on a killing spree last week to avenge his firing from the police force. Dorner outlined his grievances in a 6,000 word so-called "manifesto" and said he will keep killing until the truth is known about his case.


Dorner's threats have prompted the LAPD to provide more than 50 law enforcement families with security and surveillance detail, Beck said.


Authorities are chasing leads, however they declined to say where in order to not impede the investigation.


Dorner's burned-out truck was found Thursday near Big Bear Lake, a popular skiing destination located 80 miles northeast of Los Angeles.






Irvine Police Department/AP Photo











Manhunt for Alleged Cop Killer Heads to California Mountains Watch Video









Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video







Investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned, sources told ABC News.


The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.


Full Coverage: Christopher Jordan Dorner


Officers have spent the past couple of days going door-to-door and searching vacant cabins. The manhunt was scaled back to 25 officers and one helicopter in the resort town today, according to the San Bernadino Sheriff's Office.


On Saturday, Beck announced he would reopen the investigation into Dorner's firing but said the decision was not made to "appease" the fugitive ex-cop.


"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," Beck said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint."


Dorner is suspected of killing Monica Quan and her fiancé Keith Lawrence last Sunday in their car in the parking lot of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.


Quan's father, Randall Quan, was a retired captain with the LAPD and attorney who represented Dorner before a police review board that led to Dorner's dismissal from the force in 2008.


On Wednesday, after Dorner was identified as a suspect in the double murder, police believe he ambushed two Riverside police officers, killing one and wounding the other.


The next day, Randall Quan reported he received a taunting call from a man claiming to be Dorner who told him that he "should have done a better job of protecting his daughter," according to court documents documents.


Anyone with information leading to the arrest of Christopher Dorner is asked to call the LAPD task force at 213-486-6860.


ABC News' Dean Schabner, Jack Date, Pierre Thomas, Jason Ryan and Clayton Sandell contributed to this report.



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Sooty ships may be geoengineering by accident



































GEOENGINEERING is being tested - albeit inadvertently - in the north Pacific. Soot from oil-burning ships is dumping about 1000 tonnes of soluble iron per year across 6 million square kilometres of ocean, new research has revealed.












Fertilising the world's oceans with iron has been controversially proposed as a way of sucking carbon dioxide out of the atmosphere to curb global warming. Some geoengineers claim releasing iron into the sea will stimulate plankton blooms, which absorb carbon, but ocean processes are complex and difficult to monitor in tests.












"Experiments suggest you change the population of algae, causing a shift from fish-dominated to jellyfish-dominated ecosystems," says Alex Baker of the University of East Anglia, UK. Such concerns led the UN Convention on Biological Diversity (CBD) to impose a moratorium on geoengineering experiments in 2010.











The annual ship deposition is much larger, if less concentrated, than the iron released in field tests carried out before the moratorium was in place. Yet because ship emissions are not intended to alter ocean chemistry, they do not violate the moratorium, says Jim Thomas of the ETC Group, a think tank that consults for the CBD. "If you intentionally drove oil-burning ships back and forth as a geoengineering experiment, that would contravene it."













The new study, by Akinori Ito of the Japan Agency for Marine-Earth Science and Technology, is the first to quantify how shipping deposits iron in parts of the ocean normally deficient in it. Earlier models had assumed that only 1 to 2 per cent of the iron contained in aerosols, including shipping emissions, is soluble in seawater, so the remaining 98 to 99 percent would sink to the bottom without affecting ocean life. But Ito found that up to 80 per cent of the iron in shipping soot is soluble (Global Biogeochemical Cycles, doi.org/kdj). As this soot rapidly falls to the sea surface, it is likely to be fertilising the oceans.












In the high-latitude north Pacific - a region that is naturally iron-poor and therefore likely to be most affected by human deposits - ship emissions now account for 70 per cent of soluble iron from human activity, with the burning of biomass and coal accounting for the rest. Shipping's share will rise as traffic continues to grow and regulations restrict coal and biomass emissions.












Can we learn anything from this unintentional experiment? Baker thinks not. "The process isn't scientifically useful," he says, because the uncontrolled nature of the iron makes it difficult to draw meaningful comparisons.












The depositions are unlikely to be harmful at current levels, he says, but "given the uncertainties, I just don't know how much these iron emissions would have to increase before there was demonstrable harm to an ecosystem, or benefit in terms of carbon uptake, for that matter".


















This article appeared in print under the headline "Ships inadvertently fertilise the oceans"




















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Sony faces challenge with new PlayStation






SAN FRANCISCO: When Sony pulls back the curtain on the next-generation PlayStation videogame console, the world will see how much the Japanese consumer electronics titan has been paying attention.

Sony could double-down on hardware to power even more realistic graphics and rich game play than the impressive specifications of PlayStation 3 consoles nearing the end of a life cycle started in 2006.

Or, Sony may step towards a vision outlined by chief executive Kazuo Hirai by introducing an improved console as part of an ecosystem that weaves the company's film, music, games and electronics together with the trend towards getting home entertainment online.

"Sony needs a living room experience," Forrester Research analyst James McQuivey said while discussing expectations that a PlayStation 4 will be showcased at an event being hosted by Sony on February 20 in New York City.

"They need more software, not more hardware."

The PlayStation 3 launched as an engineering triumph complete with Blu-ray high-definition disk player capabilities only to see rival Microsoft score with Xbox 360 consoles for gaming as well as online films, music and more.

"Sony can't build a company on those few people who are hardcore gamers, so they have to figure out how to bridge to the all-purpose consumer who likes games, which is most of us," McQuivey said.

"If they emphasize how this is really a television set-top box with your favourite channels and Netflix, it will mean Sony has paid attention."

Sony has remained mum, but that hasn't stopped talk of hardware upgrades such as improved graphics and controllers with touchpads, and chatter of Sony announcing its own cable-style service to route film or music content to PlayStation consoles.

Sony needs to adapt to changing lifestyles while not alienating videogame lovers devoted to its hardware.

Low-cost or free games on smartphones or tablet computers are increasing the pressure on videogame companies to deliver experiences worth players' time and money.

New generation consoles are typically priced in the $400 to $500 range, and blockbuster game titles hit the market at $60 each.

"Sony is under a lot of pressure," said National Alliance Capital Markets analyst Mike Hickey. "Gamers are desperate for innovation and better games."

While Sony is tethered to "legacy" hardware, companies such as Apple and Google are driving innovation with tablets, smartphones, and ways to route Internet offerings to television sets, according to Hickey.

While ramping up content and services for PlayStation, Sony also needs to motivate people to upgrade from the current model.

"If Sony wants to win it, they need to show some killer games to get people to go out and spend a lot of money for the core game experience," Hickey said.

He blamed a dearth of compelling titles as a reason for disappointing sales of Nintendo's innovative Wii U consoles introduced late last year.

"The Wii U is a case study you can't ignore," Hickey said. "Sony at least has to nail it with the games; the core market can drive the mass market."

Industry tracker NPD Group reported that just shy of $9 billion was spent in the United States last year on purchasing or renting video or computer games.

Another $5.92 billion was spent on game downloads, subscriptions, and play on mobile games or at social networks, according to NPD.

French videogame star Ubisoft reported that sales surged 23 percent overall in the final quarter of last year with hit instalments of its "Assassin's Creed" and "Far Cry" franchises while online revenue leapt 143 percent.

"People are gaming more now than they ever have," McQuivey said. "More minutes on more devices over more types of games from consoles to mobile phones."

"Console gaming is going to face challenge because you can pull out your tablet and have some pretty amazing gaming experiences for $1.99 or free with ads," he added.

Forrester predicts that while US households will turn increasingly to accessing the Internet through videogame consoles and smart televisions, games on smartphones and tables will "negatively impact" the console market.

"Tablets are in every household and the computing power of tablets is going up every year," Hickey said. "Eventually, the tablet could very well become the console."

Analyst Michael Pachter of Wedbush Securities expected Sony to remain mum about pricing and specific release date while unveiling the PS4 later this month.

"The new console will clearly be more powerful," Pachter said. "How they will use that power is unclear."

- AFP/al



Read More..

Almost famous: See celebs' early roles








By Henry Hanks, CNN


updated 5:05 PM EST, Thu February 7, 2013





















Stars who started out like GoDaddy's geek


Jesse Heiman


Sylvester Stallone


John Travolta


Keanu Reeves


Courtney Cox


Matt LeBlanc


Tina Fey


Rainn Wilson


Megan Fox


Dean Winters















Read More..

Slain Texas prosecutor remembered at memorial service

TERRELL, Texas A Texas prosecutor gunned down outside his courthouse office last month was remembered Saturday for his zealousness in pursuing tough cases, love of flying and ability to tell stories.

Hundreds turned out in a school auditorium to celebrate the life of Kaufman County Assistant District Attorney Mark Hasse during a 90-minute memorial service that included stories about the veteran prosecutor's tough and softer sides as well as vows to catch his killer.

Hasse, 57, was shot multiple times the morning of Jan. 31 while walking from his car in a parking lot about a block from the courthouse. The brazen crime has sparked an investigation that includes both local and federal authorities, many of whom attended the Saturday ceremony.

Kaufman County District Attorney Mike McLelland described how Hasse, who wasn't married and had no children, never backed away from anything while often telling stories that brought laughter heard throughout the courthouse.

McLelland then turned to the effort to find Hasse's killer.

"He knows and I know there will be a reckoning," the DA said. "Too many people are focusing on that. That's not going to be a problem."

The slain prosecutor's brother, Paul Hasse, also mentioned the search for the gunman.

"You honor him by the massive effort you are making to find out who did this," he said.

Several speakers traced Hasse's career from his time as an assistant district attorney in Dallas in the 1980s to his decision three years ago to join the DA's office in Kaufman, 33 miles southeast of Dallas.

Dallas attorney Marcus Busch, who worked with Hasse in the Dallas DA's office, called Hasse "the consummate prosecutor," describing how he rose from handling cases in misdemeanor courts to being the chief of the unit charged with prosecuting organized crime. In one well-known instance, Hasse's "wicked and clever intellect" prompted him to take on a case of murder by arson that had previously been rejected, and he was able to gain a conviction, Busch said.

Busch also spoke of Hasse's love of flying and how he recovered from severe head injuries after the vintage World War II aircraft he was flying crashed in Virginia. Busch said he began taking flying lessons himself because of Hasse's passion for it.

Hasse left private practice to work as a prosecutor in Kaufman because "that's what his passion was," Busch said.

"I'd rather be in court trying a case with Mark than being in this room today," he said, stopping to gain his composure.

Cooke County DA Janice Warder, another former colleague from Hasse's Dallas days, recalled working with the prosecutor before computers put information at their fingertips. When questions would emerge from complicated autopsy reports or engineering documents, Hasse would have the answers, she said.

"Before there was Google, there was `Ask Mark,"' Warder said.

Above all else, Hasse was "ruthless when it came to fighting evil," she said.

Justin Lewis, an officer with the sheriff's department in Kaufman County who previously served as an investigator in the county DA's office, also spoke of how Hasse "enjoyed putting criminals in jail." Fighting to control his emotions, Lewis ended his remarks by saying the killer will be caught.

"Answers will eventually come," he said. "We must remain vigilant."

Read More..

LAPD Reopens Case of Suspected Cop-Killer's Firing













The Los Angeles Police Department announced today it will reopen the case of the firing of Christopher Dorner, but said the decision was not made to "appease" the fugitive former cop suspected of killing three people.


Dorner, a fired and disgruntled former Los Angeles police officer, said in the so-called "manifesto" he released that he was targeting LAPD officials and their families and will keep killing until the truth is known about his case.


"I have no doubt that the law enforcement community will bring to an end the reign of terror perpetrated on our region by Christopher Jordan Dorner and he will be held accountable for his evil actions," LAPD Chief Charlie Beck said in a statement released tonight.


He spoke of the "tremendous strides" the LAPD has made in regaining public trust, but added: "I am aware of the ghosts of the LAPD's past and one of my biggest concerns is that they will be resurrected by Dorner's allegations of racism within the Department."


To do that, he said, full re-investigation of the case that led to Dorner's firing in necessary.


"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," he said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint.






Irvine Police Department/AP Photo











Hundreds of Officers on Hunt for Alleged Cop Killer Watch Video











Christopher Dorner Manhunt: Ex-Cop Suspected in Killings Watch Video





"I do this not to appease a murderer. I do it to reassure the public that their police department is transparent and fair in all the things we do."


PHOTOS: Former LAPD Officer Suspected in Shootings


As police searched for Dorner today in the San Bernardino Mountains, sources told ABC News that investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned.


The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.


A man identifying himself as Dorner taunted the father of Monica Quan four days after the former LAPD officer allegedly killed her and just 11 hours after he allegedly killed a police officer in Riverside, Calif., according to court documents obtained by ABC News


A man claiming to be Dorner called Randall Quan and told him that that he "should have done a better job of protecting his daughter," according to the documents.


In his 6,000-word "manifesto," Dorner named Randal Quan, a retired LAPD captain and attorney who represented him before a police review board that led to Dorner's dismissal from the force.


"I never had an opportunity to have a family of my own, I'm terminating yours," Dorner wrote, and directed Quan and other officials to "[l]ook your wives/husbands and surviving children directly in the face and tell them the truth as to why your children are dead."


Monica Quan and her fiancé Keith Lawrence were gunned down last Sunday in their car in the parking of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.


The call, according to court records, was traced to Vancouver, Wash., but law enforcement officials do not believe Dorner was there at the time at the call.


Dorner is believed to have made the call early Thursday afternoon, less than half a day after he is suspected of killing a police officer and wounding two others early that morning, sparking an unprecedented man hunt involving more than a thousand police officers and federal agents spanning hundreds of miles.


FULL COVERAGE: Christopher Jordan Dorner






Read More..