State of the Union guests reflect nation's hot-button issues

Several lawmakers are bringing special guests to President Obama's State of the Union address Tuesday night in order to make a statement.

Several lawmakers are bringing guests to help underscore the importance of gun control. More than 20 House Democrats are bringing guests who have been personally affected by gun violence. A bipartisan pair of Arizona lawmakers, meanwhile, will host former Rep. Gabrielle Giffords, D-Ariz., and her husband Mark Kelly.

Other lawmakers are bringing guests tied to issues like immigration and voting rights.

Below is a partial list of officials and the guests they are bringing. CBS News will update the list as more guests are confirmed:

First Lady Michelle Obama:

• Lt. Brian Murphy, who was wounded while responding to the Sikh Temple shooting last August in Oak Creek, Wisconsin. He was struck by 15 bullets.
• Cleopatra Cowley-Pendleton and Nathaniel Pendleton Sr., parents of 15-year-old Hadiya who was killed in a Chicago park.
• Desiline Victor, a 103-year-old Florida woman who waited in line for several hours to vote.
• Tim Cook, CEO of Apple.

House Minority Leader Pelosi:

• Mother and daughter from Newtown, Conn. The 4th grader sent Pelosi a letter asking for her support to strengthen gun laws in the wake of the Sandy Hook massacre.

Sen. John McCain, R-Ariz., and Rep. Ron Barber, D-Ariz.:

• Former Rep. Gabrielle Giffords, D-Ariz., and her husband Mark Kelly

Rep. Steve Stockman, R-Texas:

• Musician and gun advocate Ted Nugent

Sens. Richard Blumenthal, D-Conn., and Chris Murphy, D-Conn.:

• First Selectwoman Pat Llodra, a Republican and the Chief Executive Officer of Newtown
• Newtown Detectives Jason Frank and Dan McAnaspie, two of several first responders who rushed to Sandy Hook Elementary School on the day of the tragedy

Rep. Luis Gutierrez, D-Ill.:

• Undocumented immigrant Gabino Sanchez. The South Carolina husband and father of two U.S. citizen children is fighting deportation. Sanchez entered the country when he was 15 years old and has been working and living peacefully in the U.S. ever since.

Sen. Dianne Feinstein, D-Calif.:

• Josh Stepakoff, who in 1999 was shot at the North Valley Jewish Community Center in Granada Hills, Calif. Stepakoff, now 20, is a student at California State University Northridge.

Sen. Frank Lautenberg, D-N.J.:

• Matt Gross, a New Jersey native who was shot in the head in 1997, at the age of 27. Gross was one of several victims wounded during a shooting attack on the observation deck of the Empire State Building.

More House Democrats bringing guests affected by gun violence:

Rep. Jim Langevin, R.I.

Rep. Keith Ellison, Minn.

Rep. Carolyn McCarthy, N.Y.

Rep. Rosa DeLauro, Conn.

Rep. David Cicilline, R.I.

Rep. Diana DeGette, Colo.

Rep. Tammy Duckworth, Ill.

Rep. Elizabeth Esty, Conn.

Rep. Lois Frankel, Fla.

Rep. Lujan Grisham, N.M.

Rep. Janice Hahn, Calif.

Rep. Jim Himes, Conn.

Rep. Alan Lowenthal, Calif.

Rep. Gloria Negrete-McLeod, Calif.

Rep. Eleanor Holmes Norton, D.C.

Rep. Ed Perlmutter, Colo.

Rep. Jan Schakowsky, Ill.

Rep. Brad Schneider, Ill.

Rep. Bobby Scott, Va.

Rep. Mike Thompson, Calif.

Rep. Krysten Sinema, Ariz.

Rep. Chris Van Hollen, Md.

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Who's Next? A Look at Likely Successors to Benedict

With 1 billion Catholics worldwide, the face of the church is changing.

It's something the cardinal electors may keep in mind when the conclave to elect a new pontiff begins in late March, said Matthew Bunson, general editor of the Catholic Almanac and author of "We Have a Pope! Benedict XVI."

RELATED: Pope Benedict XVI Resigns: The Statement

The 117 cardinals who are eligible to vote for the new pontiff hail from approximately 50 different countries, and they almost always elect one of their own.

Joseph Ratzinger, an intellectual and respected cardinal from Germany, was the frontrunner for the papacy in 2005, Bunson said. When elected, he became Pope Benedict XVI.

This year, there are no strong favorites.

"The door, in a way, is very much open," Bunson said.

FULL COVERAGE: Pope Benedict XVI Resignation

Here's a quick look at some of the possible picks for pope:

Angelo Cardinal Scola, 71, Italy

Scola was named the Archbishop of Milan in 2011, a prominent post in the Roman Catholic church.

"If we had to pick a frontrunner, it's him," Bunson said. "He first is a brilliant theologian and has the intellectual heft to be pope, which is crucial. He has the clear favor of Pope Benedict.

Milan and Venice together have produced five popes in the past century.

Scola is also committed to promoting an understanding across faiths.

He started the Oasis Foundation in 2004, which helps bridge a dialogue between Christians and Muslims.

Helen Alvaré, a professor of law at George Mason University and an advisor to Pope Benedict XVI's Pontifical Council for the Laity, agreed that Scola will be considered papabili -- an Italian word for someone highly qualified for the papacy.

"It would not be surprise me if a Scola, or another great European mind also was determined to be what was needed for the times," she said.

Marc Cardinal Ouellet, 68, Canada

The former Archbishop of Quebec, who now heads the Congregation of Bishops, has a deep knowledge of the global workings of the church, Bunson said.

"He has had a major role in the appointment of the church's leaders around the world," Bunson said.

And he points out that at 68 years old, Ouellet has age on his side.

Ouellet is someone who could have "worldwide reach," Alvaré said.

"The man who is chosen for the position he has is someone who is understood to have the presence and the future of the church in mind," she said.

Peter Cardinal Turkson, 64, Ghana

Turkson, who hails from Ghana, may be in the running.

He is currently the president of the Pontifical Council for Justice and Peace, a post he was appointed to by Pope Benedict XVI in 2009.

The job has sent Turkson, who speaks six languages, around the world to handle mediations.

"The fact that an African cardinal is a candidate to be elected pope is the statement to the diversity of the church and the remarkable growth around the world," Bunson said.

Turkson discussed the possible of a black pope at a press conference in 2009, following the U.S. presidential election.

"And if by divine providence -- because the church belongs to God -- if God would wish to see a black man also as Pope, thanks be to God," he said.

Francis Cardinal Arinze, from Nigeria, has also been discussed as a potential pope.

Leonardo Cardinal Sandri, 69, Argentina

With a large center of Catholic faithful in Latin America, Sandri could become the first pope from the region.

The 69-year-old, who was born in Argentina to Italian parents, served as a chief of staff in the Vatican, often reading public message when Pope John Paul II was in declining health.

It was Sandri who announced the passing of the pontiff in St. Peter's Square on April 2, 2005.

"He's well-liked around the world," Bunson said.

He currently serves on the Congregation for the Oriental Churches, acting as a liason with Eastern European Catholic churches.

Sandri is fluent in English, Spanish, Italian, German and French.

Angelo Cardinal Bagnasco, 70, Italy

The Archbishop of Genoa has a "reputation for intellectual heft," Bunson said.

Bagnasco, two-time president of the Italian Bishops Conference, has a history of taking a strong stance on church doctrine.

In 2007, he was the subject of death threats after he led a campaign against proposed Italian legislation to grant some legal rights to unmarried couples, including people in same-sex relationships.

Italians form the largest voting block in the College of Cardinals, with 25 percent of the seats, and could help propel Bagnasco into the papacy.

Tarsicio Cardinal Bertone, 78, Italy

The current Cardinal Secretary of State is a strong candidate if the Holy Spirit wants another great European mind at the helm of the church, Alvaré said.

Bertone runs the day-to-day business of the Roman Curia, the Vatican's government.

He has reportedly been criticized by Vatican officials for his handling of issues ranging from sexual abuse in the church to Vatican finances.

In an open letter last year, Pope Benedict XVI acknowledged the in-fighting and pledged his support for his secretary of state.

"I've noted with regret the unjust criticism directed at your person," the pope wrote. "I intend to reaffirm my pledge of personal faith in you."

Although he's held in high regard by the pope, Bunson believes Bertone's age will keep him from the papacy.

"His age is against him," he said, pointing out that Bertone is the same age as his boss when he was elected.

Timothy Cardinal Dolan, 63, New York

While the thought of an American pope has long seemed impossible, Cardinal Dolan should not be ruled out, Alvaré said.

"History is changing," she said. "We've been at this a while here in the states, [although] not anywhere as long as Europe."

Dolan, an affable cardinal well-known by Catholics in the U.S. and abroad, "has been grappling with some of the leading questions that face the church for the future," Alvaré said.

In September 2012, along with comedian Stephen Colbert, he co-led a discussion on faith and humor at Fordham University.

"If I am elected pope, which is probably the greatest gag all evening, I'll be Stephen III," he told the crowd of students.

Despite Dolan's good standing, Bunson said he has some doubts.

"It strikes me as unlikely, simply because we are the world's last superpower," he said of the U.S. "So I think that might factor in."

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Liver cancer survival time tripled by virus

The virus used in the vaccine that helped eradicate smallpox is now working its magic on liver cancer. A genetically engineered version of the vaccinia virus has trebled the average survival time of people with a severe form of liver cancer, with only mild, flu-like side effects.

Thirty people with hepatocellular carcinoma received three doses of the modified virus – code-named JX-594 – directly into their liver tumour over one month. Half the volunteers received a low dose of the virus, the other half a high dose. Members of the low and high-dose groups subsequently survived for, on average, 6.7 and 14.1 months respectively. By contrast, trials several years ago showed that sorafenib, the best existing medication for this cancer, prolonged life by only three months.

Two of the patients on the highest viral dose were still alive more than two years after the treatment. "It's a very substantial survival benefit," says Laurent Fischer, president of Jennerex, the company in San Francisco developing the treatment under the trade name Pexa-Vec.

Besides shrinking the primary tumour, the virus was able to spread to and shrink any secondary tumours outside the liver. "Some tumours disappeared completely, and most showed partial destruction on MRI scans," says David Kirn, head of the study at Jennerex. Moreover, the destruction was equally dramatic in the primary and secondary tumours.

"This clinical trial is an exciting step forward to help find a new way of treating cancers," says Alan Melcher of the University of Leeds, UK, who was not involved in the study. "It helps demonstrate the cancer-fighting potential of viruses, which have relatively few side effects compared with traditional chemo or radiotherapy," he says. "If it proves effective in larger trials, it could be available to patients within five years."

The fact that the virus appears able to spread to secondary tumours suggests that simply injecting the virus into the bloodstream may be effective. A trial to compare this treatment with injecting the virus directly into a tumour is under way.

Targeted at cancer

The virus has had a gene coding for an enzyme called thymidine kinase snipped out. The enzyme enables the virus to recognise and infect dividing cells. By removing the gene, the virus's developers have reduced the likelihood of healthy dividing cells being infected.

Instead, the virus exclusively attacks cancerous tissue, by targeting two genes that have increased activity in tumour cells. One genes is associated with an epidermal growth factor receptor, which stimulates the cancer to grow. The other is associated with a vascular endothelial growth factor, which enables the cancer to recruit its own blood supply. The virus reduces the activity of both genes, causing the infected cancer cell to wither and die.

What's more, the virus carries extra genes to prod the body's own immune system into action against the cancer. One produces granulocyte colony stimulating factor, a protein that encourages production of extra white blood cells at sites of infection. The other produces a protein not naturally found in humans, called Lac-Z, that earmarks infected cells for destruction.

Fischer says that to date, more than 200 people have received the virus, which has also shown promise against other types of cancer, including those of the kidney and skin. But he warns that not everyone sees a benefit. "We know why patients respond, but not why they don't," he says.

Journal reference: Nature Medicine, DOI: 10.1038/nm.3089

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Adele wins best pop solo performance Grammy

LOS ANGELES: British songstress Adele won the Grammy for best pop solo performance, the first award handed out during the main event on the music industry's biggest night of the year.

The 24-year-old singer, who swept the board with six Grammys at last year's awards show, took the prize for a live rendition of her hit "Set Fire to the Rain."

"My good luck charm, J-Lo," she said as she accepted the award from Jennifer Lopez and Pitbull. "This is amazing. I wanted to come and be part of the night. I loved it last year, obviously," she added.

Last year she won best song, best record, best album for her breakthrough "21," best short video, best pop album and best pop artist, winning all six categories in which she was nominated.

Indie pop band fun. won best song for "We Are Young," one of six categories in which they were nominated at music's biggest awards show.

The New York group are also shortlisted for the key categories of best record, best album and best new artist at the 55th Grammys Awards.

- AFP/ir

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Almost famous: See celebs' early roles

By Henry Hanks, CNN

updated 5:05 PM EST, Thu February 7, 2013

Stars who started out like GoDaddy's geek

Jesse Heiman

Sylvester Stallone

John Travolta

Keanu Reeves

Courtney Cox

Matt LeBlanc

Tina Fey

Rainn Wilson

Megan Fox

Dean Winters

Read More..

Tornado rips through Miss., causes major damage

HATTIESBURG, Miss. An apparent tornado tore through Hattiesburg on Sunday as part of a wave of severe storms that downed trees, damaged buildings and caused at least several injuries.

The twister traveled down one of Hattiesburg's main streets and caused what officials described as major damage, officials said, hitting several buildings on the campus of the University of Southern Mississippi. Kyle Hopkins, emergency operations director for surrounding Forrest County, said officials hadn't confirmed injuries. There were reports of several people hurt elsewhere in the state.

"We had a tornado touch down. We have a lot of damage," Hopkins said.

The university released a statement saying that several buildings had been damaged but that no injuries were reported. Campus police have declared a state of emergency and asked anyone not on campus to stay away.

Video by CBS affiliate WHLT-TV shows the heavy damage to the university, including busted windows, wood panels strewn on the lawn and fallen fences.

The storm overturned and damaged vehicles and threw debris around parts of the campus.

To the west, Marion County emergency director Aaron Greer says three injuries have been reported in the community of Pickwick, about seven miles south of Columbia. He says two people were taken to hospitals, but the third didn't have the injury examined.

Greer says one mobile home was destroyed, three other structures have major damage and several have minor damage.

National Weather Service meteorologist Joanne Culin says there have also been reports of injuries in Marion County.

Nasty weather has settled in on much of Louisiana and Mississippi, including tornado or flash flood watches.

The National Weather Service says bad weather is likely to stretch into Fat Tuesday in southeast Louisiana. Jefferson Parish has canceled a Monday night parade.

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$1M Reward for Capture of Fugitive Ex-Cop Dorner

A $1 million reward was offered today for information leading to the arrest of Christopher Dorner, as authorities in Big Bear, Calif., scaled back their search for the disgruntled ex-cop, who is suspected in three revenge killings.

"This is the largest local reward ever offered, to our knowledge," Los Angeles Police Chief Charlie Beck said at a news conference today. "This is an act of domestic terrorism. This is a man who has targeted those that we entrust to protect the public. His actions cannot go unanswered."

The money for the reward was pooled by businesses, government, local law enforcement leaders and individual donors, Beck said.

PHOTOS: Former LAPD Officer Suspected in Shootings

The reward comes on the fourth day of a manhunt for Dorner, who has left Southern California on edge after he allegedly went on a killing spree last week to avenge his firing from the police force. Dorner outlined his grievances in a 6,000 word so-called "manifesto" and said he will keep killing until the truth is known about his case.

Dorner's threats have prompted the LAPD to provide more than 50 law enforcement families with security and surveillance detail, Beck said.

Authorities are chasing leads, however they declined to say where in order to not impede the investigation.

Dorner's burned-out truck was found Thursday near Big Bear Lake, a popular skiing destination located 80 miles northeast of Los Angeles.

Irvine Police Department/AP Photo

Manhunt for Alleged Cop Killer Heads to California Mountains Watch Video

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned, sources told ABC News.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

Full Coverage: Christopher Jordan Dorner

Officers have spent the past couple of days going door-to-door and searching vacant cabins. The manhunt was scaled back to 25 officers and one helicopter in the resort town today, according to the San Bernadino Sheriff's Office.

On Saturday, Beck announced he would reopen the investigation into Dorner's firing but said the decision was not made to "appease" the fugitive ex-cop.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," Beck said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint."

Dorner is suspected of killing Monica Quan and her fiancé Keith Lawrence last Sunday in their car in the parking lot of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

Quan's father, Randall Quan, was a retired captain with the LAPD and attorney who represented Dorner before a police review board that led to Dorner's dismissal from the force in 2008.

On Wednesday, after Dorner was identified as a suspect in the double murder, police believe he ambushed two Riverside police officers, killing one and wounding the other.

The next day, Randall Quan reported he received a taunting call from a man claiming to be Dorner who told him that he "should have done a better job of protecting his daughter," according to court documents documents.

Anyone with information leading to the arrest of Christopher Dorner is asked to call the LAPD task force at 213-486-6860.

ABC News' Dean Schabner, Jack Date, Pierre Thomas, Jason Ryan and Clayton Sandell contributed to this report.

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Sooty ships may be geoengineering by accident

GEOENGINEERING is being tested - albeit inadvertently - in the north Pacific. Soot from oil-burning ships is dumping about 1000 tonnes of soluble iron per year across 6 million square kilometres of ocean, new research has revealed.

Fertilising the world's oceans with iron has been controversially proposed as a way of sucking carbon dioxide out of the atmosphere to curb global warming. Some geoengineers claim releasing iron into the sea will stimulate plankton blooms, which absorb carbon, but ocean processes are complex and difficult to monitor in tests.

"Experiments suggest you change the population of algae, causing a shift from fish-dominated to jellyfish-dominated ecosystems," says Alex Baker of the University of East Anglia, UK. Such concerns led the UN Convention on Biological Diversity (CBD) to impose a moratorium on geoengineering experiments in 2010.

The annual ship deposition is much larger, if less concentrated, than the iron released in field tests carried out before the moratorium was in place. Yet because ship emissions are not intended to alter ocean chemistry, they do not violate the moratorium, says Jim Thomas of the ETC Group, a think tank that consults for the CBD. "If you intentionally drove oil-burning ships back and forth as a geoengineering experiment, that would contravene it."

The new study, by Akinori Ito of the Japan Agency for Marine-Earth Science and Technology, is the first to quantify how shipping deposits iron in parts of the ocean normally deficient in it. Earlier models had assumed that only 1 to 2 per cent of the iron contained in aerosols, including shipping emissions, is soluble in seawater, so the remaining 98 to 99 percent would sink to the bottom without affecting ocean life. But Ito found that up to 80 per cent of the iron in shipping soot is soluble (Global Biogeochemical Cycles, doi.org/kdj). As this soot rapidly falls to the sea surface, it is likely to be fertilising the oceans.

In the high-latitude north Pacific - a region that is naturally iron-poor and therefore likely to be most affected by human deposits - ship emissions now account for 70 per cent of soluble iron from human activity, with the burning of biomass and coal accounting for the rest. Shipping's share will rise as traffic continues to grow and regulations restrict coal and biomass emissions.

Can we learn anything from this unintentional experiment? Baker thinks not. "The process isn't scientifically useful," he says, because the uncontrolled nature of the iron makes it difficult to draw meaningful comparisons.

The depositions are unlikely to be harmful at current levels, he says, but "given the uncertainties, I just don't know how much these iron emissions would have to increase before there was demonstrable harm to an ecosystem, or benefit in terms of carbon uptake, for that matter".

This article appeared in print under the headline "Ships inadvertently fertilise the oceans"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Sony faces challenge with new PlayStation

SAN FRANCISCO: When Sony pulls back the curtain on the next-generation PlayStation videogame console, the world will see how much the Japanese consumer electronics titan has been paying attention.

Sony could double-down on hardware to power even more realistic graphics and rich game play than the impressive specifications of PlayStation 3 consoles nearing the end of a life cycle started in 2006.

Or, Sony may step towards a vision outlined by chief executive Kazuo Hirai by introducing an improved console as part of an ecosystem that weaves the company's film, music, games and electronics together with the trend towards getting home entertainment online.

"Sony needs a living room experience," Forrester Research analyst James McQuivey said while discussing expectations that a PlayStation 4 will be showcased at an event being hosted by Sony on February 20 in New York City.

"They need more software, not more hardware."

The PlayStation 3 launched as an engineering triumph complete with Blu-ray high-definition disk player capabilities only to see rival Microsoft score with Xbox 360 consoles for gaming as well as online films, music and more.

"Sony can't build a company on those few people who are hardcore gamers, so they have to figure out how to bridge to the all-purpose consumer who likes games, which is most of us," McQuivey said.

"If they emphasize how this is really a television set-top box with your favourite channels and Netflix, it will mean Sony has paid attention."

Sony has remained mum, but that hasn't stopped talk of hardware upgrades such as improved graphics and controllers with touchpads, and chatter of Sony announcing its own cable-style service to route film or music content to PlayStation consoles.

Sony needs to adapt to changing lifestyles while not alienating videogame lovers devoted to its hardware.

Low-cost or free games on smartphones or tablet computers are increasing the pressure on videogame companies to deliver experiences worth players' time and money.

New generation consoles are typically priced in the $400 to $500 range, and blockbuster game titles hit the market at $60 each.

"Sony is under a lot of pressure," said National Alliance Capital Markets analyst Mike Hickey. "Gamers are desperate for innovation and better games."

While Sony is tethered to "legacy" hardware, companies such as Apple and Google are driving innovation with tablets, smartphones, and ways to route Internet offerings to television sets, according to Hickey.

While ramping up content and services for PlayStation, Sony also needs to motivate people to upgrade from the current model.

"If Sony wants to win it, they need to show some killer games to get people to go out and spend a lot of money for the core game experience," Hickey said.

He blamed a dearth of compelling titles as a reason for disappointing sales of Nintendo's innovative Wii U consoles introduced late last year.

"The Wii U is a case study you can't ignore," Hickey said. "Sony at least has to nail it with the games; the core market can drive the mass market."

Industry tracker NPD Group reported that just shy of $9 billion was spent in the United States last year on purchasing or renting video or computer games.

Another $5.92 billion was spent on game downloads, subscriptions, and play on mobile games or at social networks, according to NPD.

French videogame star Ubisoft reported that sales surged 23 percent overall in the final quarter of last year with hit instalments of its "Assassin's Creed" and "Far Cry" franchises while online revenue leapt 143 percent.

"People are gaming more now than they ever have," McQuivey said. "More minutes on more devices over more types of games from consoles to mobile phones."

"Console gaming is going to face challenge because you can pull out your tablet and have some pretty amazing gaming experiences for $1.99 or free with ads," he added.

Forrester predicts that while US households will turn increasingly to accessing the Internet through videogame consoles and smart televisions, games on smartphones and tables will "negatively impact" the console market.

"Tablets are in every household and the computing power of tablets is going up every year," Hickey said. "Eventually, the tablet could very well become the console."

Analyst Michael Pachter of Wedbush Securities expected Sony to remain mum about pricing and specific release date while unveiling the PS4 later this month.

"The new console will clearly be more powerful," Pachter said. "How they will use that power is unclear."

- AFP/al

Read More..

Almost famous: See celebs' early roles

By Henry Hanks, CNN

updated 5:05 PM EST, Thu February 7, 2013

Stars who started out like GoDaddy's geek

Jesse Heiman

Sylvester Stallone

John Travolta

Keanu Reeves

Courtney Cox

Matt LeBlanc

Tina Fey

Rainn Wilson

Megan Fox

Dean Winters

Read More..